Effect of the mannose-binding Artocarpus integer lectin on the cellular proliferation of murine lymphocytes

Lim, S.B. and Kanthimathi, M.S. and Hashim, Onn Haji (1998) Effect of the mannose-binding Artocarpus integer lectin on the cellular proliferation of murine lymphocytes. Immunological Investigations, 27 (6). pp. 395-404. ISSN 0882-0139

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Official URL: https://doi.org/10.3109/08820139809022712

Abstract

The effect of the mannose-binding champedak (Artocarpus integer) lectin-M on the cellular proliferation of murine lymphocytes was investigated in this study. Our data demonstrated that the lectin was the main mitogenic component in the crude extract of the champedak seeds. It stimulated the proliferation of murine T cells at an optimal concentration of 2.5 mu g/ml in a 3 day culture. Lectin-M appeared to be a T-cell mitogen as it does not induce significant DNA synthesis when cultured with spleen cells from the nude mouse. In the absence of T cells, the lectin was incapable of inducing resting B cells to differentiate into immunoglobulin secreting plasma cells.

Item Type: Article
Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA ---> Lim, SB Kanthimathi, MS Hashim, OH
Uncontrolled Keywords: Molecular Medicine
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 11 Jul 2012 01:34
Last Modified: 24 Oct 2019 08:14
URI: http://eprints.um.edu.my/id/eprint/3447

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