Effect of the mannose-binding Artocarpus integer lectin on the cellular proliferation of murine lymphocytes

Lim, S.B.; Kanthimathi, M.S.; Hashim, O.H. (1998) Effect of the mannose-binding Artocarpus integer lectin on the cellular proliferation of murine lymphocytes. Immunological Investigations, 27 (6). pp. 395-404. ISSN 0882-0139

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Abstract

The effect of the mannose-binding champedak (Artocarpus integer) lectin-M on the cellular proliferation of murine lymphocytes was investigated in this study. Our data demonstrated that the lectin was the main mitogenic component in the crude extract of the champedak seeds. It stimulated the proliferation of murine T cells at an optimal concentration of 2.5 mu g/ml in a 3 day culture. Lectin-M appeared to be a T-cell mitogen as it does not induce significant DNA synthesis when cultured with spleen cells from the nude mouse. In the absence of T cells, the lectin was incapable of inducing resting B cells to differentiate into immunoglobulin secreting plasma cells.

Item Type: Article
Creators:
  1. Lim, S.B.
  2. Kanthimathi, M.S.
  3. Hashim, O.H.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
Journal or Publication Title: Immunological Investigations
Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA ---> Lim, SB Kanthimathi, MS Hashim, OH
Uncontrolled Keywords: Molecular Medicine
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 11 Jul 2012 09:34
Last Modified: 11 Jul 2012 09:34
URI: http://eprints.um.edu.my/id/eprint/3447

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