Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains

Shuib, A.S.; Chua, C.T.; Hashim, O.H. (1998) Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains. Nephron, 78 (3). pp. 290-295. ISSN 0028-2766

[img]
Preview
PDF - Published Version [error in script]
Download (2883Kb) | Preview

    Abstract

    Sera of IgA nephropathy (IgAN) patients and normal subjects were analysed by two-dimensional (2-D) gel electrophoresis. Densitometric analysis of the 2-D gels of IgAN patients and normal subjects revealed that their protein maps were comparable. There was no shift of pI values in the major alpha-heavy chain spots. However, the volume of the alpha-heavy chain bands were differently distributed. Distribution was significantly lower at the anionic region in IgAN patients (mean anionic:cationic ratio of 1.184 +/- 0.311) as compared to normal healthy controls (mean anionic:cationic ratio of 2.139 +/- 0.538). Our data are in support of the previously reported findings that IgA1 of IgAN patients were lacking in sialic acid residues.

    Item Type: Article
    Journal or Publication Title: Nephron
    Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
    Uncontrolled Keywords: IgA nephropathy; α-Heavy chain; Two-dimensional electrophoresis
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 11 Jul 2012 09:33
    Last Modified: 11 Jul 2012 09:33
    URI: http://eprints.um.edu.my/id/eprint/3446

    Actions (For repository staff only: Login required)

    View Item

    Document Downloads

    More statistics for this item...