Shuib, A.S.; Chua, C.T.; Hashim, O.H. (1998) Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains. Nephron, 78 (3). pp. 290-295. ISSN 0028-2766
Sera of IgA nephropathy (IgAN) patients and normal subjects were analysed by two-dimensional (2-D) gel electrophoresis. Densitometric analysis of the 2-D gels of IgAN patients and normal subjects revealed that their protein maps were comparable. There was no shift of pI values in the major alpha-heavy chain spots. However, the volume of the alpha-heavy chain bands were differently distributed. Distribution was significantly lower at the anionic region in IgAN patients (mean anionic:cationic ratio of 1.184 +/- 0.311) as compared to normal healthy controls (mean anionic:cationic ratio of 2.139 +/- 0.538). Our data are in support of the previously reported findings that IgA1 of IgAN patients were lacking in sialic acid residues.
|Item Type: ||Article|
- Shuib, A.S.
- Chua, C.T.
- Hashim, O.H.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
|Journal or Publication Title: ||Nephron|
|Additional Information: ||Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA|
|Uncontrolled Keywords: ||IgA nephropathy; Î±-Heavy chain; Two-dimensional electrophoresis|
|Subjects: ||R Medicine|
|Divisions: ||Faculty of Medicine|
|Depositing User: ||Ms Haslinda Lahuddin|
|Date Deposited: ||11 Jul 2012 09:33|
|Last Modified: ||11 Jul 2012 09:33|
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