Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains

Shuib, A.S. and Chua, C.T. and Hashim, Onn Haji (1998) Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains. Nephron, 78 (3). pp. 290-295. ISSN 0028-2766

[img]
Preview
PDF
Sera_of_IgA_nephropathy_patients_contain_a_heterogeneous_population_of_relatively_cationic_alpha-heavy_chains.pdf - Published Version

Download (2MB)
Official URL: http://content.karger.com/ProdukteDB/produkte.asp?...

Abstract

Sera of IgA nephropathy (IgAN) patients and normal subjects were analysed by two-dimensional (2-D) gel electrophoresis. Densitometric analysis of the 2-D gels of IgAN patients and normal subjects revealed that their protein maps were comparable. There was no shift of pI values in the major alpha-heavy chain spots. However, the volume of the alpha-heavy chain bands were differently distributed. Distribution was significantly lower at the anionic region in IgAN patients (mean anionic:cationic ratio of 1.184 +/- 0.311) as compared to normal healthy controls (mean anionic:cationic ratio of 2.139 +/- 0.538). Our data are in support of the previously reported findings that IgA1 of IgAN patients were lacking in sialic acid residues.

Item Type: Article
Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: IgA nephropathy; α-Heavy chain; Two-dimensional electrophoresis
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 11 Jul 2012 01:33
Last Modified: 24 Oct 2019 08:15
URI: http://eprints.um.edu.my/id/eprint/3446

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year