Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains

Hashim, Onn Haji and Shuib, A.S. and Chua, C.T. (2001) Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains. Nephron, 89 (4). pp. 422-425. ISSN 0028-2766

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Abstract

We have studied the interaction of the Gal-GalNAc-reactive champedak lectin-C with neuraminidase-treated and untreated IgA1 from IgA nephropathy patients. The binding ability of the lectin to untreated IgA1 from IgA nephropathy patients was significantly lower as compared to the untreated IgA1 from normal controls. This differential lectin-binding capacity was abrogated when the experiment was performed on neuraminidase-treated sera. Treatment of the serum IgA1 with neuraminidase also abrogated the differential charge distribution between the alpha -heavy chains of IgA nephropathy patients and normal controls. Copyright (C) 2001 S. Karger AG, Basel.

Item Type: Article
Additional Information: Departments of Biochemistry and bMedicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Uncontrolled Keywords: IgA nephropathy; IgA1; Sialic acid; Lectin-C; α-Heavy chain; Two-dimensional gel electrophoresis
Subjects: R Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 11 Jul 2012 01:31
Last Modified: 24 Oct 2019 08:20
URI: http://eprints.um.edu.my/id/eprint/3444

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