Hashim, O.H.; Shuib, A.S.; Chua, C.T. (2001) Neuraminidase treatment abrogates the binding abnormality of IgA1 from IgA nephropathy patients and the differential charge distribution of its alpha-heavy chains. Nephron, 89 (4). pp. 422-425. ISSN 0028-2766
We have studied the interaction of the Gal-GalNAc-reactive champedak lectin-C with neuraminidase-treated and untreated IgA1 from IgA nephropathy patients. The binding ability of the lectin to untreated IgA1 from IgA nephropathy patients was significantly lower as compared to the untreated IgA1 from normal controls. This differential lectin-binding capacity was abrogated when the experiment was performed on neuraminidase-treated sera. Treatment of the serum IgA1 with neuraminidase also abrogated the differential charge distribution between the alpha -heavy chains of IgA nephropathy patients and normal controls. Copyright (C) 2001 S. Karger AG, Basel.
|Item Type: ||Article|
- Hashim, O.H.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
- Shuib, A.S.
- Chua, C.T.
|Journal or Publication Title: ||Nephron|
|Additional Information: ||Departments of Biochemistry and bMedicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia|
|Uncontrolled Keywords: ||IgA nephropathy; IgA1; Sialic acid; Lectin-C; Î±-Heavy chain; Two-dimensional gel electrophoresis|
|Subjects: ||R Medicine|
|Depositing User: ||Ms Haslinda Lahuddin|
|Date Deposited: ||11 Jul 2012 09:31|
|Last Modified: ||11 Jul 2012 09:31|
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