Kandel, Anish and Dhillon, Sarinder Kaur Kashmir Singh and Prabaharan, Chandra Bose and Hisham, Syaza Fatnin Binti and Rajamanickam, Karthic and Napper, Scott and Chidambaram, Saravana Babu and Essa, Musthafa Mohamed and Yang, Jian and Sakharkar, Meena Kishore (2021) Identifying kinase targets of PPAR gamma in human breast cancer. Journal of Drug Targeting, 29 (6). pp. 660-668. DOI https://doi.org/10.1080/1061186X.2021.1877719.
Full text not available from this repository.Abstract
Breast cancer is the most common cancer in women. Despite advances in screening women for genetic predisposition to breast cancer and risk stratification, a majority of women carriers remain undetected until they become affected. Thus, there is a need to develop a cost-effective, rapid, sensitive and non-invasive early-stage diagnostic method. Kinases are involved in all fundamental cellular processes and mutations in kinases have been reported as drivers of cancer. PPAR gamma is a ligand-activated transcription factor that plays important roles in cell proliferation and metabolism. However, the complete set of kinases modulated by PPAR gamma is still unknown. In this study, we identified human kinases that are potential PPAR gamma targets and evaluated their differential expression and gene pair correlations in human breast cancer patient dataset TCGA-BRCA. We further confirmed the findings in human breast cancer cell lines MCF7 and SK-BR-3 using a kinome array. We observed that gene pair correlations are lost in tumours as compared to healthy controls and could be used as a supplement strategy for diagnosis and prognosis of breast cancer.
| Item Type: | Article |
|---|---|
| Funders: | Natural Sciences and Engineering Research Council of Canada (NSERC)[417652], College of Pharmacy and Nutrition, University of Saskatchewan (Canada)[415458] |
| Uncontrolled Keywords: | Kinase;Breast cancer;Differential expression gene;Gene pair correlation |
| Subjects: | R Medicine R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 15 Jun 2022 06:38 |
| Last Modified: | 15 Jun 2022 06:38 |
| URI: | http://eprints.um.edu.my/id/eprint/34357 |
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