Foo, Lee Sze and Larkin, James R. and Sutherland, Brad A. and Ray, Kevin J. and Yap, Wun-She and Hum, Yan Chai and Lai, Khin Wee and Manan, Hanani Abdul and Sibson, Nicola R. and Tee, Yee Kai (2021) Study of common quantification methods of amide proton transfer magnetic resonance imaging for ischemic stroke detection. Magnetic Resonance in Medicine, 85 (4). pp. 2188-2200. ISSN 0740-3194, DOI https://doi.org/10.1002/mrm.28565.
Full text not available from this repository.Abstract
To assess the correlation and differences between common amide proton transfer (APT) quantification methods in the diagnosis of ischemic stroke. Methods Five APT quantification methods, including asymmetry analysis and its variants as well as two Lorentzian model-based methods, were applied to data acquired from six rats that underwent middle cerebral artery occlusion scanned at 9.4T. Diffusion and perfusion-weighted images, and water relaxation time maps were also acquired to study the relationship of these conventional imaging modalities with the different APT quantification methods. Results The APT ischemic area estimates had varying sizes (Jaccard index: 0.544 <= J <= 0.971) and had varying correlations in their distributions (Pearson correlation coefficient: 0.104 <= r <= 0.995), revealing discrepancies in the quantified ischemic areas. The Lorentzian methods produced the highest contrast-to-noise ratios (CNRs; 1.427 <= CNR <= 2.002), but generated APT ischemic areas that were comparable in size to the cerebral blood flow (CBF) deficit areas; asymmetry analysis and its variants produced APT ischemic areas that were smaller than the CBF deficit areas but larger than the apparent diffusion coefficient deficit areas, though having lower CNRs (0.561 <= CNR <= 1.083). Conclusion There is a need to further investigate the accuracy and correlation of each quantification method with the pathophysiology using a larger scale multi-imaging modality and multi-time-point clinical study. Future studies should include the magnetization transfer ratio asymmetry results alongside the findings of the study to facilitate the comparison of results between different centers and also the published literature.
| Item Type: | Article |
|---|---|
| Funders: | National Cancer Council Malaysia (MAKNA) Cancer Research Award 2018, UTAR Research Fund[IPSR/RMC/UTARRF/2018-C1/T04], UTAR Research Fund[IPSR/RMC/UTARRF/2020-C1/T02], Cancer Research UK[C5255/A1593], National Health and Medical Research Council (NHMRC) of Australia[APP1137776], Rebecca J. Cooper Foundation, Wellcome Trust, UK Research & Innovation (UKRI) Medical Research Council UK (MRC) European Commission[MC_ST_U13080], UK Research & Innovation (UKRI) Medical Research Council UK (MRC) European Commission[MR/K501256/1] |
| Uncontrolled Keywords: | Amide Proton Transfer (APT);Chemical Exchange Saturation Transfer (CEST);Ischemic stroke;Magnetic Resonance Imaging (MRI) |
| Subjects: | R Medicine R Medicine > R Medicine (General) > Medical technology R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Engineering |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 12 Sep 2022 04:23 |
| Last Modified: | 12 Sep 2022 04:23 |
| URI: | http://eprints.um.edu.my/id/eprint/34342 |
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