Chemically induced breast tumors in rats are detectable in early stages by contrast enhanced magnetic resonance imaging but not by changes in the acute-Phase reactants in serum

Golbabapour, S.; Pang, W.W.; George, J.; Pasupati, T.; Abdul-Rahman, P.S.; Hashim, O.H. (2011) Chemically induced breast tumors in rats are detectable in early stages by contrast enhanced magnetic resonance imaging but not by changes in the acute-Phase reactants in serum. International Journal of Molecular Sciences, 12 (2). pp. 1030-1040. ISSN 1661-6596

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    Abstract

    The present study was undertaken to develop a rat model for monitoring the early development of breast cancer. Twelve female rats were divided into two groups of six rats that were either treated with N-methyl-N-nitrosourea to induce breast cancer or with bacterial lipopolysaccharide to induce inflammation. Serum samples taken from the rats prior to the treatment were used as controls. By the 14th week, presence of the tumor was detectable by contrast enhanced magnetic resonance imaging and confirmed by histopathology. When the serum proteins of the rats were examined by 2-dimensional electrophoresis (2-DE), no difference could be detected in the profiles of all proteins before and 18 weeks after administration of N-methyl-N-nitrosourea. However, higher expression of alpha-1B glycoprotein was detectable by 2-DE in serum samples of rats at the 18th week post-treatment with lipopolysaccharide.

    Item Type: Article
    Creators:
    1. Golbabapour, S.
    2. Pang, W.W.
    3. George, J.
    4. Pasupati, T.
    5. Abdul-Rahman, P.S.
    6. Hashim, O.H.( Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    Journal or Publication Title: International Journal of Molecular Sciences
    Additional Information: Golbabapour, Shahram Pang, Wei Wei George, John Pasupati, Thanikachalam Abdul-Rahman, Puteri Shafinaz Hashim, Onn Haji
    Uncontrolled Keywords: acute-phase response; breast cancer; proteomics; magnetic resonance imaging
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 09 Jul 2012 16:48
    Last Modified: 09 Jul 2012 16:48
    URI: http://eprints.um.edu.my/id/eprint/3430

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