Functions of Burkholderia virulence factors: input from proteomics and DNA microarray analyses

Vellasamy, K.M.; Mariappan, V.; Hashim, O.; Vadivelu, J. (2012) Functions of Burkholderia virulence factors: input from proteomics and DNA microarray analyses. Journal of Analytical Science, 3 (1). pp. 72-80. ISSN 2093-3134

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Abstract

Burkholderia spp. consists of organisms that are extremely diverse and versatile with a natural habitat in the soil. Members of this genus, which include B. pseudomallei, B. mallei, B. thailandensis and B. cepacia, are capable of causing severe, life threatening opportunistic infection in patients who are immunocompromised. The underlying virulence mechanisms of the bacteria, their interactions with the host and the host defense mechanisms may be reflected by changes of the expression of proteins of both the pathogen as well as the host. In this article, we reviewed the current knowledge on interactions of Burkholderia spp. pathogens with their host mainly from the perspective of data that was generated from recent proteomics and DNA microarray investigations.

Item Type: Article
Creators:
  1. Vellasamy, K.M.
  2. Mariappan, V.
  3. Hashim, O.(Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
  4. Vadivelu, J.
Journal or Publication Title: Journal of Analytical Science
Additional Information: Department of Molecular Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
Uncontrolled Keywords: Molecular Medicine
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Ms Haslinda Lahuddin
Date Deposited: 06 Jul 2012 15:39
Last Modified: 06 Jul 2012 15:39
URI: http://eprints.um.edu.my/id/eprint/3425

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