Park, Soo-Kyung and Wong, Zhiqin and Park, Sang Hyoung and Vu, Khien Van and Bang, Ki Bae and Piyachaturawat, Panida and Myint, Thein and Hilmi, Ida Normiha and Park, Dong-Il (2021) Extraintestinal manifestation of inflammatory bowel disease in Asian patients: A multinational study. Digestive and Liver Disease, 53 (2). pp. 196-201. ISSN 1125-8055, DOI https://doi.org/10.1016/j.dld.2020.06.046.
Full text not available from this repository.Abstract
Background/aim: Although inflammatory bowel disease (IBD) incidence has increased over the past two decades in Asia, data on extraintestinal manifestations (EIMs) of IBD in Asian patients are limited. We aimed to evaluate the prevalence and clinical characteristics of EIMs in Asian IBD patients. Methods: In total, 1,764 patients (1,130 with ulcerative colitis UC] and 634 with Crohn's disease CD]) were recruited from 10 tertiary centers in Asia. The medical records of IBD patients were retrospectively reviewed for the presence, clinical characteristics, chronological order, and therapeutic management of EIMs. Results: EIMs were reported in 199 (11.3%) patients, of which 17 (1.0%) patients had multiple EIMs. EIMs were more prevalent in CD patients (P = 0.02). Multiple logistic regression analysis revealed that female sex (odds ratio OR] 2.02, 95% confidence interval CI] 1.15-3.55), stricture (OR 2.49, 95% CI 1.41-4.39) and female sex (OR 2.57, 95% CI 1.52-4.34), extensive colitis (OR 2.63, 95% CI 1.57-4.41) were associated with EIMs in CD and UC patients respectively. EIMs appeared in 8% of patients before IBD diagnosis; 95% of cases with EIM could be managed via first-line therapy. Conclusion: EIM prevalence is lower among Asian IBD patients than among patients from Western countries; however, the risk factors for EIM were similar between both populations. (C) 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | National Research Foundation of Korea[NRF-2020R1A2B5B02002259] |
| Uncontrolled Keywords: | Inflammatory bowel disease;Extraintestinal manifestation; Asian;Crohn's disease;Ulcerative colitis |
| Subjects: | R Medicine R Medicine > RA Public aspects of medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 16 Jun 2022 04:14 |
| Last Modified: | 16 Jun 2022 04:14 |
| URI: | http://eprints.um.edu.my/id/eprint/34244 |
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