Lee, Daphne S. -C. and Meiser, Bettina and Mariapun, Shivaani and Hassan, Tiara and Yip, Cheng-Har and Mohd Taib, Nur Aishah and Teo, Soo-Hwang and Thong, Meow-Keong and Yoon, Sook-Yee (2021) Communication about positive BRCA1 and BRCA2 genetic test results and uptake of testing in relatives in a diverse Asian setting. Journal of Genetic Counseling, 30 (3). pp. 720-729. ISSN 1059-7700, DOI https://doi.org/10.1002/jgc4.1360.
Full text not available from this repository.Abstract
The vast majority of studies assessing communication of BRCA1/2 results with relatives and family uptake of BRCA1/2 testing have been conducted in Western societies, and a dearth of studies have been conducted in Asia among relatives of diverse carriers of pathogenic BRCA1/2 germline variants. This study aimed to present rates of BRCA1/2 result disclosure by probands and probands' motivators and barriers of family communication and predictive testing uptake among eligible relatives. It also examined patterns of disclosure and testing uptake among different types of relatives. Eighty-seven carriers with either breast or ovarian cancer, who had previously been found to be carriers of a pathogenic variant in BRCA1/2, were interviewed over the phone using a semi-structured interview guide. Fifty-six percent of patients were Chinese, 21% were Indian, and 23% were Malay. It was found that 62.0% of eligible first- and second-degree relatives were informed by the proband about the testing result and that 11.5% of eligible first- and second-degree relatives had genetic testing. First-degree relatives were more likely to have been informed and tested compared to second-degree relatives, as were sisters compared to brothers. The low rates of family communication and testing uptake documented in this study suggest that interventions should focus on encouraging probands to inform male and second-degree relatives and targeting such relatives to increase informed decisions and accessibility to testing. Promotion strategies should be culturally sensitive to optimize outcomes.
| Item Type: | Article |
|---|---|
| Funders: | Science and Technology Development Fund (STDF) Ministry of Higher Education & Scientific Research (MHESR)[UM.C/HIR/MOHE/06], UK Research & Innovation (UKRI) Medical Research Council UK (MRC) European Commission[1078523] |
| Uncontrolled Keywords: | BRCA1;BRCA2;Cascade testing;Communication;Family;Genetic counseling;Genetic testing;Predictive genetic testing; Testing uptake |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 17 Jun 2022 04:12 |
| Last Modified: | 17 Jun 2022 04:12 |
| URI: | http://eprints.um.edu.my/id/eprint/34207 |
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