Nuclear and cellular volumetric alterations in oral lichen planus and lichenoid lesions: a histomorphometric study

Khoo, S.P. and Primasari, A. and Saub, R. (2001) Nuclear and cellular volumetric alterations in oral lichen planus and lichenoid lesions: a histomorphometric study. Journal of Oral Science, 43 (3). pp. 151-157. ISSN 1343-4934


Download (106kB)


There is presently no line of distinction between oral lichen planus and other oral lichenoid lesions. The aim of this study is to determine using histomorphometry, the differences between these lesions. Paraffin sections from 7 normal buccal epithelium, 19 oral lichen planus (LP), 14 oral lichenoid lesions (LL) and 7 discoid lupus erythematosus-like lesions (DLE-ll) were selected. The nuclear volume (V(N)) and cellular-volume (V(CELL)) of the epithelium were assessed using an image analyser. The V(N) and V(CELL), derived for both basal and spinal strata in LP and DLE-ll were 2.3 times more than that of normal tissues. There was a significant difference between LP and LL (P < 0.005) and between LL and DLE-ll (P < 0.001), but not between LP and DLE-ll. In conclusion, there appears to be a difference between LP, LL and DLE-ll and V(N) and V(CELL) may serve as potential discriminators between these groups of lesions.

Item Type: Article
Additional Information: Cited By (since 1996): 5 Export Date: 20 June 2012 Source: Scopus PubMed ID: 11732734 Language of Original Document: English Correspondence Address: Khoo,
Uncontrolled Keywords: Adult article case control study cell nucleus cell size differential diagnosis discoid lupus erythematosus epithelium cell female human lichen planus lichenoid eruption male mouth mucosa pathology retrospective study Case-Control Studies Diagnosis, Differential Epithelial Cells Lichen Planus, Oral Lichenoid Eruptions Lupus Erythematosus, Discoid Middle Age Retrospective Studies
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of Community Dentistry
Depositing User: Mr Ahmad Azwan Azman
Date Deposited: 06 Jul 2012 07:38
Last Modified: 06 Jul 2012 07:38

Actions (login required)

View Item View Item


Downloads per month over past year