Nuclear and cellular volumetric alterations in oral lichen planus and lichenoid lesions: a histomorphometric study

Khoo, S.P.; Primasari, A.; Saub, R. (2001) Nuclear and cellular volumetric alterations in oral lichen planus and lichenoid lesions: a histomorphometric study. Journal of Oral Science, 43 (3). pp. 151-157. ISSN 1343-4934

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    There is presently no line of distinction between oral lichen planus and other oral lichenoid lesions. The aim of this study is to determine using histomorphometry, the differences between these lesions. Paraffin sections from 7 normal buccal epithelium, 19 oral lichen planus (LP), 14 oral lichenoid lesions (LL) and 7 discoid lupus erythematosus-like lesions (DLE-ll) were selected. The nuclear volume (V(N)) and cellular-volume (V(CELL)) of the epithelium were assessed using an image analyser. The V(N) and V(CELL), derived for both basal and spinal strata in LP and DLE-ll were 2.3 times more than that of normal tissues. There was a significant difference between LP and LL (P < 0.005) and between LL and DLE-ll (P < 0.001), but not between LP and DLE-ll. In conclusion, there appears to be a difference between LP, LL and DLE-ll and V(N) and V(CELL) may serve as potential discriminators between these groups of lesions.

    Item Type: Article
    1. Khoo, S.P.
    2. Primasari, A.
    3. Saub, R.
    Journal or Publication Title: Journal of Oral Science
    Additional Information: Cited By (since 1996): 5 Export Date: 20 June 2012 Source: Scopus PubMed ID: 11732734 Language of Original Document: English Correspondence Address: Khoo,
    Uncontrolled Keywords: Adult article case control study cell nucleus cell size differential diagnosis discoid lupus erythematosus epithelium cell female human lichen planus lichenoid eruption male mouth mucosa pathology retrospective study Case-Control Studies Diagnosis, Differential Epithelial Cells Lichen Planus, Oral Lichenoid Eruptions Lupus Erythematosus, Discoid Middle Age Retrospective Studies
    Subjects: R Medicine > RK Dentistry
    Divisions: Faculty of Dentistry > Dept of Community Dentistry
    Depositing User: Mr Ahmad Azwan Azman
    Date Deposited: 06 Jul 2012 15:38
    Last Modified: 06 Jul 2012 15:38

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