Gan , C.S.; Wang , C.W.; Tan , K.S. (2012) Circulatory microRNA-145 expression is increased in cerebral ischemia. Genetics and Molecular Research, 11 (1). ISSN 1676-5680,
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Cerebral ischemia or ischemic stroke is mainly attributed to vascular and circulation disorders. Among protein biomarkers, RNA profiles have also been identified as markers of ischemic stroke. MicroRNA-145 expression is ostensibly recognized as marker and modulator of vascular smooth muscle cell phenotype; however, expression levels in ischemic stroke had not been investigated. Employing real-time quantitative PCR, we examined the expression profile of circulatory microRNA-145 in healthy control subjects (N = 14) and ischemic stroke patients (N = 32). Circulatory microRNA-145 expression was significantly higher in ischemic stroke patients than in control subjects. This demonstrates that hemostatic mechanisms are affected by ischemic stroke. We conclude that circulating microRNA-145 has potential as a biomarker for ischemic stroke.
| Item Type: | Article |
|---|---|
| Creators: | |
| Journal or Publication Title: | Genetics and Molecular Research |
| Additional Information: | Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. mr.dennisgan@gmail.com |
| Uncontrolled Keywords: | Molecular Medicine |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Mr. Faizal Hamzah |
| Date Deposited: | 02 Jul 2012 10:20 |
| Last Modified: | 02 Jul 2012 10:20 |
| URI: | http://eprints.um.edu.my/id/eprint/3411 |
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