Circulatory microRNA-145 expression is increased in cerebral ischemia

Gan, C.S.; Wang, C.W.; Tan, K.S. (2012) Circulatory microRNA-145 expression is increased in cerebral ischemia. Genetics and Molecular Research, 11 (1). ISSN 1676-5680,

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Abstract

Cerebral ischemia or ischemic stroke is mainly attributed to vascular and circulation disorders. Among protein biomarkers, RNA profiles have also been identified as markers of ischemic stroke. MicroRNA-145 expression is ostensibly recognized as marker and modulator of vascular smooth muscle cell phenotype; however, expression levels in ischemic stroke had not been investigated. Employing real-time quantitative PCR, we examined the expression profile of circulatory microRNA-145 in healthy control subjects (N = 14) and ischemic stroke patients (N = 32). Circulatory microRNA-145 expression was significantly higher in ischemic stroke patients than in control subjects. This demonstrates that hemostatic mechanisms are affected by ischemic stroke. We conclude that circulating microRNA-145 has potential as a biomarker for ischemic stroke.

Item Type: Article
Creators:
  1. Gan, C.S.
  2. Wang, C.W.
  3. Tan, K.S.
Journal or Publication Title: Genetics and Molecular Research
Additional Information: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. mr.dennisgan@gmail.com
Uncontrolled Keywords: Molecular Medicine
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 02 Jul 2012 10:20
Last Modified: 21 Dec 2014 18:09
URI: http://eprints.um.edu.my/id/eprint/3411

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