Zulpa, A. K. and Barathan, M. and Iyadorai, T. and Chandramathi, Samudi and Vellasamy, Kumutha Malar and Vadivelu, Jamunarani and Gan, Gin Gin and Anuar, N. A. (2021) Release of pro-inflammatory cytokines TNF-alpha, IFN-gamma and IL-6 by Burkholderia pseudomallei- stimulated peripheral blood mononucleocytes of acute myeloid leukemia patients. Tropical Biomedicine, 38 (2). pp. 180-185. ISSN 0127-5720, DOI https://doi.org/10.47665/tb.38.2.055.
Full text not available from this repository.Abstract
Acute myeloid leukemia (AML) is a malignant disease progressed from abnormal production of immature myeloid cells, which is often associated with concurrent infections after diagnosis. It was widely established that infections are the major contributors to mortality in this group due to the prevalency of neutropenia. Gram-negative Burkholderia pseudomallei is the causative agent of melioidosis. This disease had been reported in several neutropenic cancer patients undergoing chemotherapy resulting in severe clinical presentations and high mortalities which is in need of critical attention. Studies show that cytokines are important mediators of melioidosis progression and low neutrophil counts are associated with progression of its severity. However, to date, there are no reports on cytokine production in neutropenic cancer patients who are prone to melioidosis. Hence, here we assessed the cytokine production in neutropenic AML patients by introducing B. pseudomallei to their peripheral blood mononuclear cell (PBMC) culture in vitro. We observed that inflammatory response related cytokines namely TNF-alpha, IFN-gamma IL-6 and IL-10 were highly circulated in infected PBMCs suggesting that these cytokines may play important roles in the progression of severity in melioidosis infected neutropenic patients.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya [FG012-17AFR] |
| Uncontrolled Keywords: | Acute myeloid leukemia; Neutropenia; Melioidosis; Cytokines; Burkholderia pseudomallei |
| Subjects: | Q Science > QL Zoology |
| Divisions: | Faculty of Medicine > Medicine Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 27 Jun 2022 05:25 |
| Last Modified: | 27 Jun 2022 05:25 |
| URI: | http://eprints.um.edu.my/id/eprint/34015 |
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