Chua , K.H.; Chai , H.C. (2012) Hemagglutinin protein of Asian strains of human influenza virus A H1N1 binds to sialic acid--a major component of human airway receptors. Genetics and Molecular Research, 11 (1).
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Hemagglutinin (HA) protein plays an important role in binding the influenza virus to infected cells and therefore mediates infection. Deposited HA sequences of 86 Asian strains of influenza A (H1N1) viruses during the first outbreak were obtained from the NCBI database and compared. Interaction of the HA protein of influenza A (H1N1) virus with the human sialic acid receptor was also studied using bioinformatics. Overall, not more than three single-point amino acid variants/changes were observed in the HA protein region of influenza A (H1N1) virus from Asian countries when a selected group sequence comparison was made. The bioinformatics study showed that the HA protein of influenza A (H1N1) binds to the sialic acid receptor in human airway receptors, possibly key to air-borne infection in humans.
| Item Type: | Article |
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| Creators: |
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| Journal or Publication Title: | Genetics and Molecular Research |
| Additional Information: | Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. khchua@um.edu.my |
| Uncontrolled Keywords: | Molecular Medicine; influenza virus A H1N1 |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Mr. Faizal Hamzah |
| Date Deposited: | 29 Jun 2012 11:07 |
| Last Modified: | 29 Jun 2012 11:07 |
| URI: | http://eprints.um.edu.my/id/eprint/3400 |
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