The antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral Candida

Fathilah, A.R.; Himratul-Aznita, W.H.; Fatheen, A.R.N.; Suriani, K.R. (2012) The antifungal properties of chlorhexidine digluconate and cetylpyrinidinium chloride on oral Candida. Journal of Dentistry, 40 (7). pp. 609-615. ISSN 0300-5712

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      Introduction: C. tropicalis and C. krusei have emerged as virulent species causing oral infections. Both have developed resistance to commonly prescribed azole antifungal agents. Objective: The study aimed to determine the effect of mouth rinses containing chlorhexidine digluconate (CHX), cetylpyridinium chloride (CPC) and their combination (CHX-CPC) on the growth of these strains. Methods: The minimal inhibition concentrations (MIC) of the mouth rinses were determined. The growth curves of the strains produced under the mouth rinse-treated and untreated conditions, as well as alterations to the morphology of the growth colonies and cells following the treatments were compared and analysed. Results: The MICs of CPC compared to CHX mouth rinses were found to be lower for both Candida sp. In the mixed formulation, CPC doubled the inhibitory effect of CHX towards both Candida sp., while CHX quadrupled the activity of CPC towards C. tropicalis. The growth colonies also appeared coarse, wrinkled and dried. Conclusion: The profound effects shown may suggest the fungicidal activities of the mouth rinses incorporated with CHX, CPC or their combination on both C. tropicalis and C. krusei. Gargling using mouth rinses with such fungicidal activity would enhance a rapid reduction in the candidal population of patients with fungal infection.

      Item Type: Article
      1. Fathilah, A.R.
      2. Himratul-Aznita, W.H.(Department of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
      3. Fatheen, A.R.N.
      4. Suriani, K.R.
      Journal or Publication Title: Journal of Dentistry
      Additional Information: ISI Document Delivery No.: 951YK Times Cited: 0 Cited Reference Count: 33 Cited References: Hafiz A, 2012, FEMS YEAST RES, P1, DOI 10.111/j.1567-1364.2011.00786.x Kim DS, 2011, J DENT, V39, P855, DOI 10.1016/j.jdent.2011.09.010 Stanislawczuk R, 2011, J DENT, V39, P40, DOI 10.1016/j.jdent.2010.10.001 Hiraishi N, 2011, J DENT, V38, P496 Ma YL, 2010, APPL CLAY SCI, V50, P348, DOI 10.1016/j.clay.2010.08.025 Lindblad RM, 2010, J DENT, V38, P796, DOI 10.1016/j.jdent.2010.06.011 Tomas I, 2010, J DENT, V38, P541, DOI 10.1016/j.jdent.2010.03.012 Treister NS, 2010, CHEMOTHERAPY INDUCED Pusateri CR, 2009, ARCH ORAL BIOL, V54, P588, DOI 10.1016/j.archoralbio.2009.01.016 Rusni N, 2009, THESIS U MALAYA Fathilah A R, 2009, Pak J Biol Sci, V12, P518, DOI 10.3923/pjbs.2009.518.521 Neto CAF, 2008, BRAZ ORAL RES, V22, P139 Lang NP, 2008, CLIN PERIODONTOLOGY, P736 Fathilah A. R., 2007, Research Journal of Microbiology, V2, P381 Edlind MP, 2005, ANTIMICROB AGENTS CH, V49, P843, DOI 10.1128/AAC.49.2.843-845.2005 Cappuccino JG, 2005, MICROBIOLOGY LAB MAN Charles CH, 2004, J CLIN PERIODONTOL, V31, P878, DOI 10.1111/j.1600-051X.2004.00578.x Veerman ECI, 2004, BIOCHEM J, V381, P447 Herrera D, 2003, J CLIN PERIODONTOL, V30, P307, DOI 10.1034/j.1600-051X.2003.00341.x Singh S, 2002, CLIN INFECT DIS, V35, P1066, DOI 10.1086/343826 Krcmery V, 2002, J HOSP INFECT, V50, P243, DOI 10.1053/jhin.2001.1151 Quirynen M, 2001, J CLIN PERIODONTOL, V28, P1127, DOI 10.1034/j.1600-051X.2001.281207.x Cartledge JD, 1999, J ANTIMICROB CHEMOTH, V43, P419, DOI 10.1093/jac/43.3.419 Kowanko I, 1998, BEST PRACTICE, V2, P1 Samanarayake LP, 1997, HONG KONG MED J, p3, 314 Bacca LA, 1997, 75 GEN SESS IADR Hamers AD, 1996, ORAL SURG ORAL MED O, V81, P44, DOI 10.1016/S1079-2104(96)80146-6 Nakamoto K, 1995, Int J Prosthodont, V8, P486 HELLSTEIN J, 1993, J CLIN MICROBIOL, V31, P3190 Summanen P, 1993, WADSWORTH ANAEROBIC Slots J, 1992, CONT ORAL MICROBIOLO, P28 SCHEIE AA, 1989, J DENT RES, V68, P1609 Gerhardt P, 1981, MANUAL METHODS GEN B, P151 Fathilah, A. R. Himratul-Aznita, W. H. Fatheen, A. R. N. Suriani, K. R. University of MalayaRG020/09HTM This work was presented in the 'International Conference on Antimicrobial Research 2010 (ICAR2010)' in Spain. The participation was financially sponsored by the University of Malaya Conference Fund and the study was supported by the University Malaya Research Grant (RG020/09HTM). Elsevier sci ltd Oxford
      Uncontrolled Keywords: C. tropicalis C. krusei Growth curves Oral mucositis Fungicidal activity in-vitro albicans formulations mouthrinse resistance dentin agents
      Subjects: R Medicine > RK Dentistry
      Divisions: Faculty of Dentistry > Dept of Oral Biology
      Depositing User: Mr Ahmad Azwan Azman
      Date Deposited: 29 Jun 2012 10:18
      Last Modified: 30 May 2017 20:23

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