Azratul-Hizayu, T. and Chen, C. D. and Lau, K. W. and Azrizal-Wahid, N. and Tan, T. K. and Lim, Y. A. L. and Sofian-Azirun, M. and Low, V. L. (2021) Bioefficacy of mosquito mat vaporizers and associated metabolic detoxication mechanisms in Aedes aegypti (Linnaeus) in Selangor, Malaysia: A statewide assessment. Tropical Biomedicine, 38 (3). pp. 327-337. ISSN 0127-5720, DOI https://doi.org/10.47665/tb.38.3.073.
Full text not available from this repository.Abstract
This study aims to examine the efficacy of mosquito mat vaporizers on Aedes aegypti and their associated metabolic detoxication mechanisms. For this purpose, Aedes aegypti (Linnaeus) was collected from nine districts in Selangor, Malaysia and tested with mosquito vaporizing mat bioassays. The same populations were also subjected to biochemical assays to investigate activities of detoxifying enzymes, namely non-specific esterase (EST), glutathione-S-transferase (GST) and mixed function oxidase (MFO). The efficacy of Ae. aegypti on the active ingredients tested in decreasing order were d- allethrin > dimefluthrin > prallethrin with PBO > prallethrin. The results further indicated significant enhancement mean levels of EST, GST and MFO in pyrethroid-resistant populations. The mortality rate of Ae. aegypti in response to pyrethroid active ingredients was associated with MFO activity, suggesting it is an important detoxification enzyme for the populations tested. In view of the presence of resistance against household insecticide products, pyrethroid efficacy on Ae. aegypti populations needs to be monitored closely to ensure the implementation of an effective vector control program in Malaysia.
| Item Type: | Article |
|---|---|
| Funders: | Higher Institution Centre of Excellence (HICoE) program [MO002-2019], Universiti Malaya [RP021C/16SUS] |
| Uncontrolled Keywords: | Resistance; Mosquito mat vaporizer; Biochemical assays; Pyrethroid; Aedes |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 17 Jul 2022 04:25 |
| Last Modified: | 17 Jul 2022 04:25 |
| URI: | http://eprints.um.edu.my/id/eprint/33893 |
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