Hepatoprotective effects of panus giganteus (Berk.) corner against Thioacetamide- (TAA-) induced liver injury in Rats.

Wong, W.L.; Abdulla, M.A.; Chua, K.H.; Kuppusamy, U.R.; Tan, Y.S.; Sabaratnam, V. (2012) Hepatoprotective effects of panus giganteus (Berk.) corner against Thioacetamide- (TAA-) induced liver injury in Rats. Evidence-based Complementary and Alternative Medicine. ISSN 1741-427X

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    Abstract

    Panus giganteus, a culinary and medicinal mushroom consumed by selected indigenous communities in Malaysia, is currently being considered for large scale cultivation. This study was undertaken to investigate the hepatoprotective effects of P. giganteus against thioacetamide- (TAA-) induced liver injury in Sprague-Dawley rats. The rats were injected intraperitoneally with TAA thrice weekly and were orally administered freeze-dried fruiting bodies of P. giganteus (0.5 or 1 g/kg) daily for two months, while control rats were given vehicle or P. giganteus only. After 60 days, rats administered with P. giganteus showed lower liver body weight ratio, restored levels of serum liver biomarkers and oxidative stress parameters comparable to treatment with the standard drug silymarin. Gross necropsy and histopathological examination further confirmed the hepatoprotective effects of P. giganteus. This is the first report on hepatoprotective effects of P. giganteus. The present study showed that P. giganteus was able to prevent or reduce the severity of TAA-induced liver injury.

    Item Type: Article
    Creators:
    1. Wong, W.L.
    2. Abdulla, M.A.
    3. Chua, K.H.
    4. Kuppusamy, U.R.
    5. Tan, Y.S.
    6. Sabaratnam, V.
    Journal or Publication Title: Evidence-based Complementary and Alternative Medicine
    Additional Information: Mushroom Research Centre, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia----> Correspondence should be addressed to Mahmood Ameen Abdulla, mahmood955@yahoo.com
    Subjects: R Medicine
    Divisions: Faculty of Science
    Depositing User: Mr. Faizal Hamzah
    Date Deposited: 21 Jun 2012 17:27
    Last Modified: 12 Dec 2014 14:07
    URI: http://eprints.um.edu.my/id/eprint/3389

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