Phang, Wei Kit and Bukhari, Fatma Diyana Mohd and Zen, Lee Phone Youth and Jaimin, Joel Judson and Dony, Jiloris Julian Frederick and Lau, Yee Ling (2022) Genetic polymorphism of circumsporozoite protein (CSP) in Plasmodium malariae isolates from Malaysia. Parasitology International, 87. ISSN 1383-5769, DOI https://doi.org/10.1016/j.parint.2021.102519.
Full text not available from this repository.Abstract
Information about Plasmodium malariae is scanty worldwide due to its ``benign'' nature and low infection rates. Consequently, studies on the genetic polymorphisms of P. malariae are lacking. Here, we report genetic polymorphisms of 28 P. malariae circumsporozoite protein (Pmcsp) isolates from Malaysia which were compared with those in other regions in Asia as well as those from Africa. Phylogenetic analysis revealed that most Malaysian P. malariae isolates clustered together but independently from other Asian isolates. Low nucleotide diversity was observed in Pmcsp non-repeat regions in contrast to high nucleotide diversity observed in non-repeat regions of Plasmodium knowlesi CSP gene, the current major cause of malaria in Malaysia. This study contributes to the characterisation of naturally occurring polymorphisms in the P. malariae CSP gene.
| Item Type: | Article |
|---|---|
| Funders: | Long Term Research Grant Scheme by Ministry of Education Malaysia [Grant No: LRGS/1/2018/UM/01/1/4 (LR002A-2018)] |
| Uncontrolled Keywords: | Plasmodium malariae; Circumsporozoite protein; Malaysia; Malaria |
| Subjects: | Q Science > QR Microbiology R Medicine > RX Homeopathy > Diseases, treatment, etc |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Jul 2022 04:38 |
| Last Modified: | 20 Jul 2022 04:38 |
| URI: | http://eprints.um.edu.my/id/eprint/33685 |
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