Toh, Tzi Shin and Chong, Chun Wie and Lim, Shen-Yang and Bowman, Jeff and Cirstea, Mihai and Lin, Chin-Hsien and Chen, Chieh-Chang and Appel-Cresswell, Silke and Finlay, B. Brett and Tan, Ai Huey (2022) Gut microbiome in Parkinson's disease: New insights from meta-analysis. Parkinsonism & Related Disorders, 94. pp. 1-9. ISSN 1353-8020, DOI https://doi.org/10.1016/j.parkreldis.2021.11.017.
Full text not available from this repository.Abstract
Background: Gut microbiome alterations have been reported in Parkinson's disease (PD), but with heterogenous findings, likely due to differences in study methodology and population. We investigated the main microbiome alterations in PD, their correlations with disease severity, and the impact of study and geographical differences. Methods: After systematic screening, raw 16S rRNA gene sequences were obtained from ten case-control studies totaling 1703 subjects (969 PD, 734 non-PD controls; seven predominantly Caucasian and three predominantly non-Caucasian cohorts). Quality-filtered gene sequences were analyzed using a phylogenetic placement approach, which precludes the need for the sequences to be sourced from similar regions in the 16S rRNA gene, thus allowing a direct comparison between studies. Differences in microbiome composition and correlations with clinical variables were analyzed using multivariate statistics. Results: Study and geography accounted for the largest variations in gut microbiome composition. Microbiome composition was more similar for subjects from the same study than those from different studies with the same disease status. Microbiome composition significantly differed between Caucasian and non-Caucasian populations. After accounting for study differences, microbiome composition was significantly different in PD vs. controls (albeit with a marginal effect size), with several distinctive features including increased abundances of Megasphaera and Akkermansia, and reduced Roseburia. Several bacterial genera correlated with PD motor severity, motor response complications and cognitive function. Conclusion: Consistent microbial features in PD merit further investigation. The large variations in microbiome findings of PD patients underscore the need for greater harmonization of future research, and personalized approaches in designing microbial-directed therapeutics.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia Fundamental Research Grant Scheme (FRGS) [Grant No: FRGS/1/2018/SKK02/UM/02/1], Marg Meikle Professorship for Parkinson's disease by the Pacific Parkinson's Research Institute (PPRI), Parkinson Canada, Parkinson Society British Columbia |
| Uncontrolled Keywords: | Gut microbiome; Gut dysbiosis; Gut-brain-axis; 16S rRNA; Parkinson's disease |
| Subjects: | R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 20 Jul 2022 04:47 |
| Last Modified: | 20 Jul 2022 04:47 |
| URI: | http://eprints.um.edu.my/id/eprint/33677 |
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