Venkatraman, Senthil Kumar and Choudhary, Rajan and Vijayakumar, Naveensubramaniam and Krishnamurithy, Genasan and Raghavendran, Hanumantha Rao Balaji and Murali, Malliga Raman and Kamarul, Tunku and Suresh, Anushree and Abraham, Jayanthi and Swamiappan, Sasikumar (2022) Investigation on bioactivity, mechanical stability, bactericidal activity and in-vitro biocompatibility of magnesium silicates for bone tissue engineering applications. Journal of Materials Research, 37 (2). pp. 608-621. ISSN 0884-2914, DOI https://doi.org/10.1557/s43578-021-00450-9.
Full text not available from this repository.Abstract
The current work reports the biocompatibility and mechanical stability of enstatite and forsterite bioceramics prepared by sol-gel combustion method. XRD results conferred that enstatite and forsterite phase formation take place at 1000 degrees C and 900 degrees C respectively.TEM micrographs indicated the particle size of enstatite in the micron range while forsterite is in the range of 100-200 nm. The FT-IR spectra of forsterite after biomineralization revealed the presence of phosphate and carbonate groups shows apatite deposition ability of forsterite. The slow degradation and better apatite deposition of forsterite resulted in ten folds greater compressive strength than enstatite. Both the bioceramics have shown a remarkable impact on inhibiting the growth of clinical pathogens at a very low concentration. The good hBMSCs attachment and significant proliferation revealed the cytocompatibility of enstatite and forsterite. These observations suggested that magnesium silicate bioceramics can be explored for load-bearing applications, maxillofacial reconstruction and septic arthritis.
| Item Type: | Article |
|---|---|
| Funders: | Vellore Institute of Technology (VIT) management, European Union's Horizon 2020 research and innovation program [Grant No: 857287], Science and Technology Development Fund (STDF) Ministry of Higher Education & Scientific Research (MHESR) [Grant No: FRGS/1/2016/SKK08/UM/02/20] |
| Uncontrolled Keywords: | Bioactivity; Mechanical stability; Bactericidal activity; Magnesium silicates; Bone tissue engineering applications |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 01 Aug 2022 01:46 |
| Last Modified: | 01 Aug 2022 01:46 |
| URI: | http://eprints.um.edu.my/id/eprint/33481 |
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