Chong, Mei Yan and Gu, Boram and Armour, Chloe Harriet and Dokos, Socrates and Ong, Zhi Chao and Xu, Xiao Yun and Lim, Einly (2022) An integrated fluid-structure interaction and thrombosis model for type B aortic dissection. Biomechanics and Modeling in Mechanobiology, 21 (1). pp. 261-275. ISSN 1617-7959, DOI https://doi.org/10.1007/s10237-021-01534-5. (In Press)
Full text not available from this repository.Abstract
False lumen thrombosis (FLT) in type B aortic dissection has been associated with the progression of dissection and treatment outcome. Existing computational models mostly assume rigid wall behavior which ignores the effect of flap motion on flow and thrombus formation within the FL. In this study, we have combined a fully coupled fluid-structure interaction (FSI) approach with a shear-driven thrombosis model described by a series of convection-diffusion reaction equations. The integrated FSI-thrombosis model has been applied to an idealized dissection geometry to investigate the interaction between vessel wall motion and growing thrombus. Our simulation results show that wall compliance and flap motion can influence the progression of FLT. The main difference between the rigid and FSI models is the continuous development of vortices near the tears caused by drastic flap motion up to 4.45 mm. Flap-induced high shear stress and shear rates around tears help to transport activated platelets further to the neighboring region, thus speeding up thrombus formation during the accelerated phase in the FSI models. Reducing flap mobility by increasing the Young's modulus of the flap slows down the thrombus growth. Compared to the rigid model, the predicted thrombus volume is 25% larger using the FSI-thrombosis model with a relatively mobile flap. Furthermore, our FSI-thrombosis model can capture the gradual effect of thrombus growth on the flow field, leading to flow obstruction in the FL, increased blood viscosity and reduced flap motion. This model is a step closer toward simulating realistic thrombus growth in aortic dissection, by taking into account the effect of intimal flap and vessel wall motion.
| Item Type: | Article |
|---|---|
| Funders: | Royal Society-Newton Advanced Fellowship [Grant No: NA170094], PhD scholarship through Engineering and Physical Sciences Research Council Doctoral Training Partnership [Grant No: EP/R512540/1] |
| Uncontrolled Keywords: | Aortic dissection (AD); Fluid-structure interaction (FSI); Computational fluid dynamics (CFD); Intimal flap motion; Thrombus formation |
| Subjects: | Q Science > QC Physics T Technology > TA Engineering (General). Civil engineering (General) |
| Divisions: | Faculty of Engineering |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Aug 2022 03:26 |
| Last Modified: | 03 Aug 2022 03:26 |
| URI: | http://eprints.um.edu.my/id/eprint/33458 |
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