Tegginamani, Anand S. and Shivakumar, Vanishree H. and Ismail, Siti Mazlipah and Abraham, Mannil T. and Fernandes, Bennete A. and Zamzuri, Ahmad Termizi B. (2022) C-kit expression in oral leukoplakia. Journal of the College of Physicians and Surgeons Pakistan, 32 (2). pp. 256-258. ISSN 1022-386X, DOI https://doi.org/10.29271/jcpsp.2022.02.256.
Full text not available from this repository.Abstract
Oral leukoplakia is the most common potentially malignant oral disorder. Oral leukoplakia's malignant potential is independent of the histopathological grade, and the malignant transformation rate varies greatly from 3% to 50% even in the case of severe epithelial dysplasia. Ethnic & environmental variables may contribute to this variation. C-kit immunohistochemistry was performed on 15 oral leukoplakia (OL), two oral squamous cell carcinoma (OSCC), and two dentigerous cysts (DC). The objective of this study was to evaluate the c-kit expression in oral leukoplakia. The use of various immunohistochemical markers to differentiate between OLs with a high and low risk of malignant transformation has been investigated. Only four OL exhibited a faint cytoplasmic expression in basal cells. Whereas, OSCC and DC were devoid of c-kit expression. Thus, this may not be a unique marker for identifying OL at high-risk. Further research with larger sample size is required.
| Item Type: | Article |
|---|---|
| Funders: | SEGi University Research Grant [SEGiuni/VC/RIMC/33/19-12-2016] |
| Uncontrolled Keywords: | CD 117; Disease progression; Oral dysplasia; Oral leukoplakia; Risk prediction |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry > Dept of Oral & Maxillofacial Surgery |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 03 Aug 2022 01:26 |
| Last Modified: | 03 Aug 2022 01:26 |
| URI: | http://eprints.um.edu.my/id/eprint/33442 |
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