Khutami, Chindiana and Sumiwi, Sri Adi and Khairul Ikram, Nur Kusaira and Muchtaridi, Muchtaridi (2022) The effects of antioxidants from natural products on obesity, dyslipidemia, diabetes and their molecular signaling mechanism. International Journal of Molecular Sciences, 23 (4). ISSN 1422-0067, DOI https://doi.org/10.3390/ijms23042056.
Full text not available from this repository.Abstract
Obesity is a risk factor that leads to the development of other diseases such as dyslipidemia and diabetes. These three metabolic disorders can occur simultaneously, hence, the treatment requires many drugs. Antioxidant compounds have been reported to have activities against obesity, dyslipidemia and diabetes via several mechanisms. This review aims to discuss the antioxidant compounds that have activity against obesity, dyslipidemia and diabetes together with their molecular signaling mechanism. The literature discussed in this review was obtained from the PUBMED database. Based on the collection of literature obtained, antioxidant compounds having activity against the three disorders (obesity, dyslipidemia and diabetes) were identified. The activity is supported by various molecular signaling pathways that are influenced by these antioxidant compounds, further study of which would be useful in predicting drug targets for a more optimal effect. This review provides insights on utilizing one of these antioxidant compounds as opposed to several drugs. It is hoped that in the future, the number of drugs in treating obesity, dyslipidemia and diabetes altogether can be minimized consequently reducing the risk of side effects.
| Item Type: | Article |
|---|---|
| Funders: | Rector of Universitas Padjadjaran [Grant No: 1959/UN6.3.1/PT.00/2021] |
| Uncontrolled Keywords: | Obesity; Oxidative stress; Dyslipidemia; Diabetes; Antioxidant |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 04 Aug 2022 02:30 |
| Last Modified: | 04 Aug 2022 02:30 |
| URI: | http://eprints.um.edu.my/id/eprint/33418 |
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