Hyaluronic acid with or without bone marrow derived-mesenchymal stem cells improves osteoarthritic knee changes in rat model: a preliminary report

Suhaeb, A.M.; Naveen, S.; Mansor, A.; Kamarul, T. (2011) Hyaluronic acid with or without bone marrow derived-mesenchymal stem cells improves osteoarthritic knee changes in rat model: a preliminary report. Indian Journal of Experimental Biology, 50. pp. 383-390. ISSN 0975-1009

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    Abstract

    Despite being a complex degenerative joint disease, studies on osteoarthritis (OA) suggest that its progression can be reduced by the use of hyaluronic acid (HA) or mesenchymal stem cells (MSC). The present study thus aims to examine the effects of MSC, HA and the combination of HA-MSC in treating OA in rat model. The histological observations using O'Driscoll score indicate that it is the use of HA and MSC independently and not their combination that delays the progression of OA. In conclusion, the preliminary study suggest that the use of either HA or MSCs effectively reduces OA progression better than their combined use.

    Item Type: Article
    Creators:
    1. Suhaeb, A.M.
    2. Naveen, S.
    3. Mansor, A.(Department of Orthopaedic Surgery, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    4. Kamarul, T.(Department of Orthopaedic Surgery, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    Journal or Publication Title: Indian Journal of Experimental Biology
    Additional Information: Department of Orthopaedic Surgery, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
    Uncontrolled Keywords: Hyaluronic acid, Mesenchymal stem cells, Monosodium iodoacetate, Osteoarthritis rat model
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 19 Jun 2012 09:06
    Last Modified: 19 Jun 2012 09:06
    URI: http://eprints.um.edu.my/id/eprint/3323

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