Tan , L.Y.; Yin , W.F.; Chan , K.G. (2012) Silencing quorum sensing through extracts of Melicope lunu-ankenda. Sensors (Basel)., 12 (4).
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Abstract
Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden salad, inhibited response of Chromobacterium violaceum CV026 to N-hexanoylhomoserine lactone, thus interfering with violacein production; reduced bioluminescence expression of E. coli [pSB401], disrupted pyocyanin synthesis, swarming motility and expression of lecA::lux of Pseudomonas aeruginosa PAO1. Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds.
| Item Type: | Article |
|---|---|
| Creators: | |
| Journal or Publication Title: | Sensors (Basel). |
| Additional Information: | Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mails: etaly87@yahoo.com (L.Y.T.); yinwaifong@yahoo.com (W.-F.Y.) |
| Uncontrolled Keywords: | Anti-quorum sensing; bioluminescence; leca::lux; malaysian plants; N-acyl-l-homoserine lactones (ahl); pseudomonas aeruginosa pao1; pyocyanin; Virulence; swarming motility |
| Subjects: | Q Science > Q Science (General) R Medicine |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Mr. Faizal Hamzah |
| Date Deposited: | 18 Jun 2012 10:22 |
| Last Modified: | 18 Jun 2012 10:22 |
| URI: | http://eprints.um.edu.my/id/eprint/3321 |
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