Tan, L.Y.; Yin, W.F.; Chan, K.G. (2012) Silencing quorum sensing through extracts of Melicope lunu-ankenda. Sensors (Basel)., 12 (4).
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Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden salad, inhibited response of Chromobacterium violaceum CV026 to N-hexanoylhomoserine lactone, thus interfering with violacein production; reduced bioluminescence expression of E. coli [pSB401], disrupted pyocyanin synthesis, swarming motility and expression of lecA::lux of Pseudomonas aeruginosa PAO1. Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds.
|Journal or Publication Title:||Sensors (Basel).|
|Additional Information:||Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mails: firstname.lastname@example.org (L.Y.T.); email@example.com (W.-F.Y.)|
|Uncontrolled Keywords:||Anti-quorum sensing; bioluminescence; leca::lux; malaysian plants; N-acyl-l-homoserine lactones (ahl); pseudomonas aeruginosa pao1; pyocyanin; Virulence; swarming motility|
|Subjects:||Q Science > Q Science (General)|
|Divisions:||Faculty of Science > Institute of Biological Sciences|
|Depositing User:||Mr. Faizal Hamzah|
|Date Deposited:||18 Jun 2012 10:22|
|Last Modified:||11 Dec 2013 14:46|
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