Silencing quorum sensing through extracts of Melicope lunu-ankenda.

Tan, L.Y.; Yin, W.F.; Chan, K.G. (2012) Silencing quorum sensing through extracts of Melicope lunu-ankenda. Sensors (Basel)., 12 (4).

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    Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden salad, inhibited response of Chromobacterium violaceum CV026 to N-hexanoylhomoserine lactone, thus interfering with violacein production; reduced bioluminescence expression of E. coli [pSB401], disrupted pyocyanin synthesis, swarming motility and expression of lecA::lux of Pseudomonas aeruginosa PAO1. Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds.

    Item Type: Article
    1. Tan, L.Y.
    2. Yin, W.F.
    3. Chan, K.G.
    Journal or Publication Title: Sensors (Basel).
    Additional Information: Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mails: (L.Y.T.); (W.-F.Y.)
    Uncontrolled Keywords: Anti-quorum sensing; bioluminescence; leca::lux; malaysian plants; N-acyl-l-homoserine lactones (ahl); pseudomonas aeruginosa pao1; pyocyanin; Virulence; swarming motility
    Subjects: Q Science > Q Science (General)
    R Medicine
    Divisions: Faculty of Science > Institute of Biological Sciences
    Depositing User: Mr. Faizal Hamzah
    Date Deposited: 18 Jun 2012 10:22
    Last Modified: 11 Dec 2013 14:46

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