Silencing quorum sensing through extracts of Melicope lunu-ankenda

Tan, L.Y. and Yin, W.F. and Chan, Kok Gan (2012) Silencing quorum sensing through extracts of Melicope lunu-ankenda. Sensors, 12 (4). pp. 4339-4351. ISSN 1424-8220, DOI https://doi.org/10.3390/s120404339.

Preview

PDF 7.pdf Download (758kB)

Abstract

Quorum sensing regulates bacterial virulence determinants, therefore making it an interesting target to attenuate pathogens. In this work, we screened edible, endemic plants in Malaysia for anti-quorum sensing properties. Extracts from Melicope lunu-ankenda (Gaertn.) T. G. Hartley, a Malay garden salad, inhibited response of Chromobacterium violaceum CV026 to N-hexanoylhomoserine lactone, thus interfering with violacein production; reduced bioluminescence expression of E. coli [pSB401], disrupted pyocyanin synthesis, swarming motility and expression of lecA::lux of Pseudomonas aeruginosa PAO1. Although the chemical nature of the anti-QS compounds from M. lunu-ankenda is currently unknown, this study proves that endemic Malaysian plants could serve as leads in the search for anti-quorum sensing compounds.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia; E-Mails: etaly87@yahoo.com (L.Y.T.); yinwaifong@yahoo.com (W.-F.Y.)
Uncontrolled Keywords:	Anti-quorum sensing; Bioluminescence; Leca::lux; Malaysian plants; N-acyl-l-homoserine lactones (ahl); Pseudomonas aeruginosa pao1; Pyocyanin; Virulence; Swarming motility
Subjects:	Q Science > Q Science (General) R Medicine
Divisions:	Faculty of Science > Institute of Biological Sciences
Depositing User:	Mr. Faizal Hamzah
Date Deposited:	18 Jun 2012 02:22
Last Modified:	30 Oct 2018 01:54
URI:	http://eprints.um.edu.my/id/eprint/3321

Actions (login required)

View Item