Wyer, Scott and Townsend, Danyelle M. and Ye, Zhiwei and Kourtidis, Antonis and Choo, Yeun-Mun and de Barros, Andre Luis Branco and Donia, Mohamed S. and Hamann, Mark T. (2022) Recent advances and limitations in the application of kahalalides for the control of cancer. Biomedicine & Pharmacotherapy, 148. ISSN 0753-3322, DOI https://doi.org/10.1016/j.biopha.2022.112676.
Full text not available from this repository.Abstract
Since the discovery of the kahalalide family of marine depsipeptides in 1993, considerable work has been done to develop these compounds as new and biologically distinct anti-cancer agents. Clinical trials and laboratory research have yielded a wealth of data that indicates tolerance of kahalalides in healthy cells and selective activity against diseased cells. Currently, two molecules have attracted the greates level of attention, kahalalide F (KF) and isokahalalide F (isoKF, Irvalec, PM 02734, elisidepsin). Both compounds were originally isolated from the sarcoglossan mollusk Elysia rufescens but due to distinct structural characteristics it has been hypothesized and recently shown that the ultimate origin of the molecules is microbial. The search for their true source has been a subject of considerable research in the anticipation of finding new analogs and a culturable expression system that can produce sufficient material through fermentation to be industrially relevant.
| Item Type: | Article |
|---|---|
| Funders: | United States Department of Health & Human Services National Institutes of Health (NIH) - USA[R01 DK124553], United States Department of Health & Human Services National Institutes of Health (NIH) - USA[R21 CA246233] |
| Uncontrolled Keywords: | 16SrRNA;Akt;Anti-psoriatic;Bryopsis;Cancer;Cytochrome c oxidase I;Cytotoxicity;Depsipeptide;Elisidepsin;ErbB;GLPORYx;Her2;Her3;Isokahalalide;Kahalalide A;Kahalalide G;Kahalalide;MAPK;Mollusk;Oncosis |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 17 Aug 2022 04:37 |
| Last Modified: | 17 Aug 2022 04:37 |
| URI: | http://eprints.um.edu.my/id/eprint/32739 |
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