Kanmalar, M. and Abdul Sani, Siti Fairus and Kamri, Nur Izzahtul Nabilla B. and Mohd Said, Nur Akmarina and Abd Jamil, Amirah Hajirah and Kuppusamy, S. and Mun, Kien Seong and Bradley, D. A. (2022) Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: A review. Cellular & Molecular Biology Letters, 27 (1). ISSN 1689-1392, DOI https://doi.org/10.1186/s11658-022-00307-x.
Full text not available from this repository.Abstract
Bladder cancer is the fourth most common malignancy in males. It can present across the whole continuum of severity, from mild through well-differentiated disease to extremely malignant tumours with poor survival rates. As with other vital organ malignancies, proper clinical management involves accurate diagnosis and staging. Chemotherapy consisting of a cisplatin-based regimen is the mainstay in the management of muscle-invasive bladder cancers. Control via cisplatin-based chemotherapy is threatened by the development of chemoresistance. Intracellular cholesterol biosynthesis in bladder cancer cells is considered a contributory factor in determining the chemotherapy response. Farnesyl-diphosphate farnesyltransferase 1 (FDFT1), one of the main regulatory components in cholesterol biosynthesis, may play a role in determining sensitivity towards chemotherapy compounds in bladder cancer. FDFT1-associated molecular identification might serve as an alternative or appendage strategy for early prediction of potentially chemoresistant muscle-invasive bladder cancer tissues. This can be accomplished using Raman spectroscopy. Developments in the instrumentation have led to it becoming one of the most convenient forms of analysis, and there is a highly realistic chance that it will become an effective tool in the pathology lab. Chemosensitive bladder cancer tissues tend to have a higher lipid content, more protein genes and more cholesterol metabolites. These are believed to be associated with resistance towards bladder cancer chemotherapy. Herein, Raman peak assignments have been tabulated as an aid to indicating metabolic changes in bladder cancer tissues that are potentially correlated with FDFT1 expression.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya [IIRG022B-2019] |
| Uncontrolled Keywords: | Bladder cancer; Diagnostic; FDFT1; Cisplatin chemoresistance; Raman spectroscopy |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine > Pathology Department Faculty of Science > Department of Physics Faculty of Pharmacy > Department of Pharmaceutical Life Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 12 Aug 2022 00:15 |
| Last Modified: | 12 Aug 2022 00:15 |
| URI: | http://eprints.um.edu.my/id/eprint/32718 |
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