Autologous chondrocyte transplantation in the repair of full-thickness focal cartilage damage in rabbits

Kamarul, T.; Selvaratnam, L.; Masjuddin, T.; Ab-Rahim, S.; Ng, C.; Chan, K.Y.; Ahmad, T.S.T. (2008) Autologous chondrocyte transplantation in the repair of full-thickness focal cartilage damage in rabbits. Journal of Orthopaedic Surgery, 16 (2). pp. 84-87. ISSN 1022-5536

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    PURPOSE:To compare the efficacy of autologous chondrocyte transplantation (ACT) versus non-operative measures for cartilage repair in rabbits. METHODS:Nine New Zealand white rabbits were used. Identical focal defects were created in the articular cartilage of both knees. One month later, the right knee was repaired via ACT, while the left knee was left untreated (control group). The quality of cartilage tissues in both knees was compared 3 months later, according to the quantitative analysis of glycosaminoglycan (GAG) in the cartilage and macroscopic examination of histology using the Brittberg/International Cartilage Research Society (ICRS) score. RESULTS:Microscopic examination showed enhanced regeneration following ACT repair. Quantification analysis revealed significantly higher cellular expression of GAG in the ACT-treated knees (1.12 vs 0.81 microgram GAGs/mg protein, p=0.008). The mean Brittberg/ICRS score was significantly higher in the treated knees (6.00 vs 1.89, p=0.007). CONCLUSION: ACT is superior to non-operative measures for repairing focal cartilage defects, as determined by favourable histological and immunohistological outcomes at the cellular level.

    Item Type: Article
    1. Kamarul, T.(Department of Orthopaedic Surgery, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    2. Selvaratnam, L.
    3. Masjuddin, T.
    4. Ab-Rahim, S.
    5. Ng, C.
    6. Chan, K.Y.
    7. Ahmad, T.S.T.
    Journal or Publication Title: Journal of Orthopaedic Surgery
    Additional Information: Tissue Engineering Group, Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
    Uncontrolled Keywords: Cartilage; Chondrocytes; Tissue Engineering; Transplantation, Autologous
    Subjects: R Medicine
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 07 Jun 2012 14:46
    Last Modified: 28 Oct 2014 14:13

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