Epitope mapping of the Sta58 major outer membrane protein of Rickettsia tsutsugamushi.

Lachumanan, R.; Devi, S.; Cheong, Y.M.; Rodda, S.J.; Pang, T. (1993) Epitope mapping of the Sta58 major outer membrane protein of Rickettsia tsutsugamushi. Infection and immunity, 61 (10). pp. 4527-31. ISSN 0019-9567

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Abstract

Binding studies of 160 overlapping, synthetic octapeptides from the hydrophilic regions of the Sta58 major outer membrane protein of Rickettsia tsutsugamushi with sera from patients with scrub typhus revealed 15 immunodominant peptides which are recognized by all the sera tested. Further analysis of the specificity of peptide binding with five of these peptides indicated that the peptides showed significantly stronger binding to scrub typhus patients' sera than they did to sera from patients with other febrile illnesses common in the region, i.e., malaria, dengue fever, typhoid fever, and leptospirosis. The main antibody class binding to these peptides appears to be immunoglobulin M, and there appears to be little correlation between reactivity with peptides and antibody titers measured by the indirect immunoperoxidase test.

Item Type: Article
Creators:
  1. Lachumanan, R.
  2. Devi, S.
  3. Cheong, Y.M.
  4. Rodda, S.J.
  5. Pang, T.
Journal or Publication Title: Infection and immunity
Additional Information: Institute of Advanced Studies, University of Malaya, Kuala Lumpur.
Uncontrolled Keywords: Amino Acid Sequence; Antibodies, Bacterial/immunology; Antigens, Bacterial/chemistry; Antigens, Bacterial/immunology;
Subjects: R Medicine > R Medicine (General)
Divisions: UNSPECIFIED
Depositing User: Mr. Faizal Hamzah
Date Deposited: 02 Mar 2011 16:37
Last Modified: 11 Dec 2013 15:37
URI: http://eprints.um.edu.my/id/eprint/319

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