The promise of human induced pluripotent stem cells in dental research

Srijaya, T.C.; Pradeep, P.J.; Zain, R.B.; Musa, S.; Abu Kasim, N.H.; Govindasamy, V. The promise of human induced pluripotent stem cells in dental research. Stem Cells International. ISSN 1687-966X

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    Abstract

    Induced pluripotent stem cell-based therapy for treating genetic disorders has become an interesting field of research in recent years. However, there is a paucity of information regarding the applicability of induced pluripotent stem cells in dental research. Recent advances in the use of induced pluripotent stem cells have the potential for developing disease-specific iPSC lines in vitro from patients. Indeed, this has provided a perfect cell source for disease modeling and a better understanding of genetic aberrations, pathogenicity, and drug screening. In this paper, we will summarize the recent progress of the disease-specific iPSC development for various human diseases and try to evaluate the possibility of application of iPS technology in dentistry, including its capacity for reprogramming some genetic orodental diseases. In addition to the easy availability and suitability of dental stem cells, the approach of generating patient-specific pluripotent stem cells will undoubtedly benefit patients suffering from orodental disorders.

    Item Type: Article
    Creators:
    1. Srijaya, T.C.
    2. Pradeep, P.J.
    3. Zain, R.B.
    4. Musa, S.
    5. Abu Kasim, N.H.
    6. Govindasamy, V.
    Journal or Publication Title: Stem Cells International
    Uncontrolled Keywords: Dental Research
    Subjects: R Medicine > RK Dentistry
    Divisions: Faculty of Dentistry > Dept of Children’s Dentistry And Orthodontics
    Depositing User: Associate Professor Dr. Sabri Musa
    Date Deposited: 17 May 2012 09:39
    Last Modified: 19 Dec 2014 10:38
    URI: http://eprints.um.edu.my/id/eprint/3178

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