Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts.

Awang , K.; Abdullah , N.H.; Hadi , A.H.; Su Fong , Y. (2012) Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts. Journal of Biomedicine and Biotechnology. ISSN 1110-7243

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    Abstract

    The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant. Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart.

    Item Type: Article
    Creators:
    1. Awang , K.(University of Malaya)
    2. Abdullah , N.H.
    3. Hadi , A.H.
    4. Su Fong , Y.
    Journal or Publication Title: Journal of Biomedicine and Biotechnology
    Additional Information: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia Correspondence should be addressed to Khalijah Awang, khalijah@um.edu.my
    Uncontrolled Keywords: Cardiovascular
    Subjects: R Medicine
    Divisions: Faculty of Science > Dept of Chemistry
    Depositing User: Mr. Faizal Hamzah
    Date Deposited: 16 May 2012 10:04
    Last Modified: 16 May 2012 10:04
    URI: http://eprints.um.edu.my/id/eprint/3168

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