Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts

Awang, Khalijah and Abdullah, N.H. and Hadi, A.H. and Su Fong, Y. (2012) Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts. Journal of Biomedicine and Biotechnology. ISSN 1110-7243

[img]
Preview
PDF (Full Text)
1.pdf

Download (600kB)
Official URL: http://www.ncbi.nlm.nih.gov/pubmed/22536026

Abstract

The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant. Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart.

Item Type: Article
Additional Information: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia Correspondence should be addressed to Khalijah Awang, khalijah@um.edu.my
Uncontrolled Keywords: Cardiovascular
Subjects: R Medicine
Divisions: Faculty of Science > Dept of Chemistry
Depositing User: Mr. Faizal Hamzah
Date Deposited: 16 May 2012 02:04
Last Modified: 08 Mar 2019 08:35
URI: http://eprints.um.edu.my/id/eprint/3168

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year