The effect of pretreatment with plant extract, nicotine and caffeine on sleeping time induced by pentobarbitone in mice

Robson , N. (2008) The effect of pretreatment with plant extract, nicotine and caffeine on sleeping time induced by pentobarbitone in mice. Internet Journal of Pharmacology, 5 (2). ISSN 1531-2976

[img]
Preview
PDF [error in script]
Download (181Kb) | Preview

    Abstract

    Objective: To determine the effects of plant extract, nicotine and caffeine on the activities of the liver metabolizing-enzyme induced by pentobarbitone. Materials and Method: Seven groups of mice were pretreated with high doses of sample extracts (0.4 mg/g body weight sample extract, but nicotine at 0.1 mg/g body weight) and one control group was pretreated with saline. On day 5, pentobarbitone (0.005 ml of 8 mg/ml) was administered and the sleeping time was determined. The test was repeated but at low doses (0.1 mg/g body weight sample extract, but nicotine at 0.05mg/g body weight). Results: At high doses, bitter gourd, 'tempeh', nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the activities of liver metabolizing enzyme significantly compared to control. At low doses, bitter gourd, nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the enzyme but 'tempeh' did not. Conclusion: The findings suggest that bitter gourd, nicotine and caffeine act as enzyme inducers, but 'tempeh' only demonstrate this ability at high dose.

    Item Type: Article
    Creators:
    1. Robson , N.(University of Malaya)
    Journal or Publication Title: Internet Journal of Pharmacology
    Uncontrolled Keywords: Cytochrome P450, Liver Metabolizing-Enzyme, Plant Extracts, Enzyme Inducer, Nicotine, Caffeine
    Subjects: H Social Sciences > H Social Sciences (General)
    R Medicine > R Medicine (General)
    Divisions: Faculty of Medicine
    Depositing User: Noorzurani Robson
    Date Deposited: 17 May 2012 09:58
    Last Modified: 17 May 2012 09:58
    URI: http://eprints.um.edu.my/id/eprint/3150

    Actions (For repository staff only: Login required)

    View Item

    Document Downloads

    More statistics for this item...