The effect of pretreatment with plant extract, nicotine and caffeine on sleeping time induced by pentobarbitone in mice

Robson, N. (2008) The effect of pretreatment with plant extract, nicotine and caffeine on sleeping time induced by pentobarbitone in mice. Internet Journal of Pharmacology, 5 (2). ISSN 1531-2976

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Abstract

Objective: To determine the effects of plant extract, nicotine and caffeine on the activities of the liver metabolizing-enzyme induced by pentobarbitone. Materials and Method: Seven groups of mice were pretreated with high doses of sample extracts (0.4 mg/g body weight sample extract, but nicotine at 0.1 mg/g body weight) and one control group was pretreated with saline. On day 5, pentobarbitone (0.005 ml of 8 mg/ml) was administered and the sleeping time was determined. The test was repeated but at low doses (0.1 mg/g body weight sample extract, but nicotine at 0.05mg/g body weight). Results: At high doses, bitter gourd, 'tempeh', nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the activities of liver metabolizing enzyme significantly compared to control. At low doses, bitter gourd, nicotine, caffeine, nicotine+bitter gourd, nicotine+'tempeh' and nicotine+caffeine induced the enzyme but 'tempeh' did not. Conclusion: The findings suggest that bitter gourd, nicotine and caffeine act as enzyme inducers, but 'tempeh' only demonstrate this ability at high dose.

Item Type: Article
Uncontrolled Keywords: Cytochrome P450, Liver Metabolizing-Enzyme, Plant Extracts, Enzyme Inducer, Nicotine, Caffeine
Subjects: H Social Sciences > H Social Sciences (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine
Depositing User: Noorzurani Robson
Date Deposited: 17 May 2012 01:58
Last Modified: 28 Oct 2014 05:39
URI: http://eprints.um.edu.my/id/eprint/3150

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