A review of histomorphometric analysis techniques for assessing implant-soft tissue interface

Chai, W.L. and Moharamzadeh, K. and Brook, I.M. and VanNoort, R. (2011) A review of histomorphometric analysis techniques for assessing implant-soft tissue interface. Biotechnic & Histochemistry, 86 (4). pp. 242-254. ISSN 1052-0295


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The success of dental implant treatment depends on the healing of both hard and soft tissues. While osseointegration provides initial success, the biological seal of the peri-implant soft tissue is crucial for maintaining the long term success of implants. Most studies of the biological seal of peri-implant tissues are based on animal or monolayer cell culture models. To understand the mechanisms of soft tissue attachment and the factors affecting the integrity of the soft tissue around the implants, it is essential to obtain good quality histological sections for microscopic examination. The nature of the specimens, however, which consist of both metal implant and soft peri-implant tissues, poses difficulties in preparing the specimens for histomorphometric analysis of the implant-soft tissue interface. We review various methods that have been used for the implant-tissue interface investigation with particular focus on the soft tissue. The different methods are classified and the advantages and limitations of the different techniques are highlighted.

Item Type: Article
Additional Information: Times Cited: 1
Uncontrolled Keywords: Dental implants Histomorphometric analysis Interface Soft tissue titanium animal confocal microscopy human immunohistochemistry methodology pathology review scanning electron microscopy soft tissue injury surface property tooth implantation wound healing Animals Humans Microscopy, Confocal Microscopy, Electron, Scanning Soft Tissue Injuries Surface Properties Animalia
Subjects: R Medicine > RK Dentistry
Divisions: Faculty of Dentistry > Dept of General Dental Practice And Oral & Maxillofacial Imaging
Depositing User: Associate Professor Dr. Wen Lin Chai
Date Deposited: 03 May 2012 01:37
Last Modified: 03 May 2012 01:37
URI: http://eprints.um.edu.my/id/eprint/3099

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