Gender-dependent association of a �²2-adrenergic gene variant with obesity parameters in Malaysian Malays

Apalasamy, Y.D.; Ming, M.F.; Rampal, S.; Bulgiba, A.; Mohamed, Z. (2011) Gender-dependent association of a �²2-adrenergic gene variant with obesity parameters in Malaysian Malays. Asia-Pacific Journal of Public Health. ISSN 1010-5395

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Abstract

Recent findings have shown that the rs1042714 (Gln27Glu) single-nucleotide polymorphism (SNP) on the β2-adrenoceptor gene may predispose to obesity. The findings from other studies carried on different populations, however, have been inconsistent. The authors investigated the association between the rs1042714 SNP with obesity-related parameters. DNA of 672 Malaysian Malays was analyzed using real-time polymerase chain reaction. Univariate and multivariate linear regression analyses revealed significant associations between rs1042714 and diastolic blood pressure in the pooled Malaysian Malay subjects under additive and recessive models. After gender stratification, however, a significant association was found between the rs1042714 and triglyceride and the rs1042714 and log-transformed high-density lipoprotein cholesterol levels in Malaysian Malay men. No significant association was found between the SNP and log-transformed body mass index. This polymorphism may have an important role in the development of obesity-related traits in Malaysian Malays. Gender is an effect modifier for the effect of the rs1042714 polymorphism on obesity-related traits in Malaysian Malays.

Item Type: Article
Creators:
  1. Apalasamy, Y.D.
  2. Ming, M.F.
  3. Rampal, S.
  4. Bulgiba, A.(Department of Social and Preventive Medicine, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
  5. Mohamed, Z.
Journal or Publication Title: Asia-Pacific Journal of Public Health
Additional Information: Suggested Citation : Apalasamy YD, Ming MF, Rampal S, Bulgiba A, Mohamed Z. Gender-Dependent Association of a β2-Adrenergic Gene Variant With Obesity Parameters in Malaysian Malays. Asia-Pacific Journal of Public Health. 2011.
Uncontrolled Keywords: Obesity Parameters
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Awang Bulgiba Awang Mahmud
Date Deposited: 09 May 2012 15:47
Last Modified: 09 May 2012 15:47
URI: http://eprints.um.edu.my/id/eprint/3066

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