Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women.

Yelumalai, Suseela and Muniandy, Sekaran and Zawiah Omar, Siti and Qvist, Rajes (2010) Pregnancy-induced hypertension and preeclampsia: levels of angiogenic factors in malaysian women. Journal of Clinical Biochemistry and Nutrition, 47 (3). pp. 191-7. ISSN 1880-5086, DOI 21103027.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/21103027

Abstract

Preeclampsia (PE) is a major contributor to maternal and fetal mortality. The cause of preeclampsia remains unclear, but oxidative stress on the endothelium leading to endothelial dysfunction is said to be the root cause of the disease. The aim of this study was to measure and determine the plasma levels of key angiogenic factors in pregnancy as an indicator for the early onset of preeclampsia in pregnancy. Plasma levels of circulating a soluble fms like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor, vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), both pro-angiogenic factors were analyzed in normal pregnant Malaysian women (control group, n = 34), women with pregnant induced hypertension (PIH, n = 34) and women with preeclampsia (PE, n = 34) all at three gestational ages, 24-28 weeks (early pregnancy: EP), 32-36 weeks (late pregnancy: LP) and 6 weeks after delivery (postpartum: PN). The plasma levels of angiogenic factors were determined by ELISA. sFlt-1 levels were elevated in PIH and PE patients as compared to controls. PIGF and VEGF were significantly decreased in PIH and PE as compared to the controls. These results suggest that elevated concentration of sFlt-1 and suppressed levels of PIGF and VEGF may contribute to the development of hypertension in pregnancy which precedes preeclampsia.

Item Type: Article
Funders: UNSPECIFIED
Uncontrolled Keywords: hypertension; preeclampsia;
Subjects: R Medicine > RZ Other systems of medicine
Depositing User: Zanaria Saupi Udin
Date Deposited: 02 Mar 2011 05:17
Last Modified: 02 Mar 2011 05:17
URI: http://eprints.um.edu.my/id/eprint/305

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