Over-expression of MAGED4B increases cell migration and growth in oral squamous cell carcinoma and is associated with poor disease outcome

Chong, Chan Eng; Lim, Kue Peng; Gan, Chai Phei; Marsh, Christina A.; Zain, R.B.; Abraham, Mannil Thomas; Prime, Stephen S.; Teo, Soo-Hwang; Gutkind, J.S.; Patel, Vyomesh; Cheong, Sok Ching (2012) Over-expression of MAGED4B increases cell migration and growth in oral squamous cell carcinoma and is associated with poor disease outcome. Cancer Letters. ISSN 0304-3835

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    Abstract

    MAGE proteins have been shown to be good targets for cancer immunotherapy. We demonstrate that MAGED4B is over-expressed in more than 50 of Oral Squamous Cell Carcinoma (OSCC) tissues and the expression of MAGED4B is associated with lymph node metastasis and poor disease specific survival. OSCC cell lines that over-express MAGED4B promote migration in vitro, exhibit an increase in cell growth both in vitro and in vivo, and are more resistant to apoptosis compared to control cells. Our data suggest that MAGED4B over-expression is a driver in oral carcinogenesis and argues strongly that this protein may represent a potential therapeutic target in OSCC.

    Item Type: Article
    Creators:
    1. Chong, Chan Eng
    2. Lim, Kue Peng
    3. Gan, Chai Phei
    4. Marsh, Christina A.
    5. Zain, R.B.(Department of Oral Pathology and Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya)
    6. Abraham, Mannil Thomas
    7. Prime, Stephen S.
    8. Teo, Soo-Hwang
    9. Gutkind, J.S.
    10. Patel, Vyomesh
    11. Cheong, Sok Ching
    Journal or Publication Title: Cancer Letters
    Additional Information: Department of Oral Pathology and Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya
    Uncontrolled Keywords: MAGED4B Melanoma antigens Oral Squamous Cell Carcinoma (OSCC) Migration
    Subjects: R Medicine
    R Medicine > RK Dentistry
    Divisions: Faculty of Dentistry > Dept of Oral Pathology & Oral Medicine & Periodontology
    Depositing User: Prof. Dr. Rosnah Mohd Zain
    Date Deposited: 08 May 2012 11:33
    Last Modified: 11 Dec 2014 14:16
    URI: http://eprints.um.edu.my/id/eprint/3036

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