Oscillations and waves of intracellular CA2+ in cardiac-muscle-cells

Orchard, C. H.; Mustafa, M. R.; White, E. (1995) Oscillations and waves of intracellular CA2+ in cardiac-muscle-cells. Chaos Solitons & Fractals, 5 (3-4). pp. 447-458. ISSN 0960-0779

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    Abstract

    When cardiac muscle cells become overloaded with Ca2+, spontaneous releases of Ca2+ from the sarcoplasmic reticulum can occur. Such spontaneous releases normally originate within a localized region of the cell and propagate as a wave throughout the cell. The amplitude and frequency of these Ca2+ releases increase with the degree of Ca2+ loading of the cell, and are abolished by interventions which inhibit sarcoplasmic reticulum function. It is still not clear whether these releases are triggered by a rise in the Ca2+ in the lumen of the sarcoplasmic reticulum or by a rise in cytoplasmic Ca2+. Such releases may, however, by activating inward currents, depolarize the cell membrane and thus be arrhythmogenic; they may also, by decreasing the amount of Ca2+ within the sarcoplasmic reticulum, decrease the strength of a stimulated contraction.

    Item Type: Article
    Creators:
    1. Orchard, C. H.
    2. Mustafa, M. R.(Department of Pharmacology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    3. White, E.
    Journal or Publication Title: Chaos Solitons & Fractals
    Additional Information: Department of Pharmacology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
    Uncontrolled Keywords: Pharmacology
    Subjects: R Medicine
    Divisions: Faculty of Medicine > School of Biological Sciences
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 08 May 2012 11:29
    Last Modified: 08 May 2012 11:29
    URI: http://eprints.um.edu.my/id/eprint/3034

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