Naucline, a new indole alkaloid from the bark of nauclea officinalis

Liew, S.Y.; Mukhtar, M.R.; Hadi, A.H.A.; Awang, K.; Mustafa, M.R.; Zaima, K.; Morita, H.; Litaudon, M. (2012) Naucline, a new indole alkaloid from the bark of nauclea officinalis. Molecules, 17 (4). pp. 4028-4036. ISSN 1420-3049

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    Abstract

    A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete 13C-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90 relaxation at 1 � 10�5 M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90 relaxation at 1 � 10�5 M) on an isolated rat aorta.

    Item Type: Article
    Creators:
    1. Liew, S.Y.(Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    2. Mukhtar, M.R.(Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    3. Hadi, A.H.A.(Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    4. Awang, K.(Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia)
    5. Mustafa, M.R.(Department of Pharmacology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    6. Zaima, K.(Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan)
    7. Morita, H.(Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan)
    8. Litaudon, M.(Institut de Chimie de la Substances Naturelles, Centre Nationale de la Recherches Scientifique, 91198, Gif-sur Yvette, Cedex, France)
    Journal or Publication Title: Molecules
    Uncontrolled Keywords: naucline; angustine; angustidine; nauclefine; naucletine; Rubiaceae; vasorelaxant activity
    Subjects: R Medicine
    Divisions: Faculty of Medicine > School of Biological Sciences
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 08 May 2012 09:22
    Last Modified: 11 Dec 2014 14:14
    URI: http://eprints.um.edu.my/id/eprint/3028

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