Liew, Sook Yee; Mukhtar, Mat Ropi; Hadi, A. Hamid A.; Awang, Khalijah; Mustafa, Mohd Rais; Zaima, Kazumasa; Morita, Hiroshi; Litaudon, Marc (2012) Naucline, a new indole alkaloid from the bark of nauclea officinalis. Molecules, 17 (4). pp. 4028-4036. ISSN 1420-3049
Abstract
A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete 13C-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90 relaxation at 1 � 10�5 M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90 relaxation at 1 � 10�5 M) on an isolated rat aorta.
| Item Type: | Article |
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| Creators: | - Liew, Sook Yee
- Mukhtar, Mat Ropi
- Hadi, A. Hamid A.
- Awang, Khalijah
- Mustafa, Mohd Rais(Department of Pharmacology, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
- Zaima, Kazumasa
- Morita, Hiroshi
- Litaudon, Marc
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| Journal or Publication Title: | Molecules |
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| Uncontrolled Keywords: | naucline; angustine; angustidine; nauclefine; naucletine; Rubiaceae; vasorelaxant activity |
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| Subjects: | R Medicine |
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| Divisions: | Faculty of Medicine > School of Biological Sciences |
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| Depositing User: | Ms Haslinda Lahuddin |
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| Date Deposited: | 08 May 2012 09:22 |
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| Last Modified: | 08 May 2012 09:22 |
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| URI: | http://eprints.um.edu.my/id/eprint/3028 |
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