Naucline, a new indole alkaloid from the bark of nauclea officinalis

Liew, Sook Yee and Mukhtar, M.R. and Hadi, A.H.A. and Awang, Khalijah and Mustafa, Mohd Rais and Zaima, K. and Morita, H. and Litaudon, M. (2012) Naucline, a new indole alkaloid from the bark of nauclea officinalis. Molecules, 17 (4). pp. 4028-4036. ISSN 1420-3049, DOI https://doi.org/10.3390/molecules17044028.

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Abstract

A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete 13C-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90 relaxation at 1 � 10�5 M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90 relaxation at 1 � 10�5 M) on an isolated rat aorta.

Item Type:	Article
Funders:	UNSPECIFIED
Uncontrolled Keywords:	naucline; angustine; angustidine; nauclefine; naucletine; Rubiaceae; vasorelaxant activity
Subjects:	R Medicine
Divisions:	Faculty of Medicine > School of Biological Sciences
Depositing User:	Ms Haslinda Lahuddin
Date Deposited:	08 May 2012 01:22
Last Modified:	01 Mar 2019 09:17
URI:	http://eprints.um.edu.my/id/eprint/3028

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