An update on imatinib mesylate therapy in chronic myeloid leukaemia patients in a teaching hospital in Malaysia

Bee, P.C; Gan, G.G.; Tai, Y.T.; Haris, A.R.; Chin, E.; Veera, S.N. (2012) An update on imatinib mesylate therapy in chronic myeloid leukaemia patients in a teaching hospital in Malaysia. Singapore Medical Journal, 53 (1). pp. 57-61. ISSN 0037-5675

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Abstract

INTRODUCTION: The introduction of imatinib mesylate in 1998 has changed the management of chronic myeloid leukaemia. It is now the first-line therapy for newly diagnosed chronic myeloid leukaemia patients worldwide. However, its long-term survival benefit still needs to be established in clinical setting among Asian patients. METHODS: All chronic myeloid leukaemia patients in the chronic phase who were on imatinib mesylate therapy were retrospectively reviewed. Data was collected through a review of case notes, which was then processed, managed and analysed. RESULTS: A total of 44 patients were included in the study. The cumulative rates of complete haematological response, major cytogenetic response and major molecular response were 93.2%, 75.0% and 34.2%, respectively. The overall survival and event-free survival at five years were 86.0% and 84.9%, respectively. 31.8% of the patients developed anaemia, 29.5% neutropenia and 27.3% thrombocytopenia. A total of 43.2% of patients developed non-haematological side effects. Higher dosage (> 600 mg) and smaller body size (< 60 kg) were risk factors for haematological side effects. Patients with major cytogenetic response and absence of thrombocytopenia had better survival. CONCLUSION: The majority of our chronic myeloid leukaemia patients did well with imatinib therapy. The adverse effects in our patients were tolerable, and no patient had to stop treatment permanently.

Item Type: Article
Creators:
  1. Bee, P.C
  2. Gan, G.G.
  3. Tai, Y.T.
  4. Haris, A.R.
  5. Chin, E.
  6. Veera, S.N.
Journal or Publication Title: Singapore Medical Journal
Additional Information: Medical Department, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. bpingchong@yahoo.com
Uncontrolled Keywords: Medicine; Myeloid Leukaemia Patients
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 27 Mar 2012 09:15
Last Modified: 11 Dec 2013 10:33
URI: http://eprints.um.edu.my/id/eprint/2983

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