Bee, P.C. and Gan, G.G. and Tai, Y.T. and Haris, A.R. and Chin, E. and Veera, S.N. (2012) An update on imatinib mesylate therapy in chronic myeloid leukaemia patients in a teaching hospital in Malaysia. Singapore Medical Journal, 53 (1). pp. 57-61. ISSN 0037-5675, DOI PMID: 22252185.
Full text not available from this repository.Abstract
INTRODUCTION: The introduction of imatinib mesylate in 1998 has changed the management of chronic myeloid leukaemia. It is now the first-line therapy for newly diagnosed chronic myeloid leukaemia patients worldwide. However, its long-term survival benefit still needs to be established in clinical setting among Asian patients. METHODS: All chronic myeloid leukaemia patients in the chronic phase who were on imatinib mesylate therapy were retrospectively reviewed. Data was collected through a review of case notes, which was then processed, managed and analysed. RESULTS: A total of 44 patients were included in the study. The cumulative rates of complete haematological response, major cytogenetic response and major molecular response were 93.2%, 75.0% and 34.2%, respectively. The overall survival and event-free survival at five years were 86.0% and 84.9%, respectively. 31.8% of the patients developed anaemia, 29.5% neutropenia and 27.3% thrombocytopenia. A total of 43.2% of patients developed non-haematological side effects. Higher dosage (> 600 mg) and smaller body size (< 60 kg) were risk factors for haematological side effects. Patients with major cytogenetic response and absence of thrombocytopenia had better survival. CONCLUSION: The majority of our chronic myeloid leukaemia patients did well with imatinib therapy. The adverse effects in our patients were tolerable, and no patient had to stop treatment permanently.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Medical Department, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. bpingchong@yahoo.com |
| Uncontrolled Keywords: | Medicine; Myeloid Leukaemia Patients |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Mr. Faizal Hamzah |
| Date Deposited: | 27 Mar 2012 01:15 |
| Last Modified: | 21 Dec 2014 08:03 |
| URI: | http://eprints.um.edu.my/id/eprint/2983 |
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