Lee, Shiaw Xian and Tan, Chun Hoe and Mah, Wee Li and Wong, Richard Chee Seng and Cheow, Yuen Lin and Sim, Kae Shin and Tan, Kong Wai (2021) Synthesis of group 6 (chromium, molybdenum, and tungsten) photoCORMs as potential antimicrobial and anticancer agents. Inorganica Chimica Acta, 525. ISSN 0020-1693, DOI https://doi.org/10.1016/j.ica.2021.120491.
Full text not available from this repository.Abstract
A new ligand 1 (1,10-phenanthrolin-5-amine, N-(2-fluorenylmethylene)) was synthesized and reacted with group 6 metal carbonyls to form UV activable photoCORMs with the formulation of M(1)(CO)4 (M = Cr, Mo, and W, which correspond to 2, 3, and 4, respectively). All synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR, CHN elemental analysis, and single crystal X-ray diffraction. Compounds 2-4 contain four COs bonded to the metal centre displaying distorted octahedral geometry, and the CO can be released via UV (365 nm) illumination. Compound 2 displayed the shortest half-life and shortest CO-releasing rate when tested using modified three-layered myoglobin solution assay. All compounds generally showed no appreciable antibacterial activities, with or without the illumination of UV light, except for 2 which demonstrated considerable antifungal activity against Candida albicans and C. tropicalis. In contrast, compounds 1-4 exhibited potent cytotoxicity against human colorectal cancer cell lines (HT-29 and HCT 116) and 2-4 displayed strong photo-induced cytotoxicity against the same cell lines with remarkedly high selectivity.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education & Scientific Research (MHESR)[FRGS/1/2015/SG01/UM/02/4], Universiti Malaya Research Grant[RP033A17AFR] |
| Uncontrolled Keywords: | Co-releasing molecules;Iron-oxide nanoparticles:Biological-activity;Visible-light;Complexes;Derivatives;Carbonyl;Binding;Trigger;Design |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 19 Aug 2022 08:00 |
| Last Modified: | 19 Aug 2022 08:00 |
| URI: | http://eprints.um.edu.my/id/eprint/28785 |
Actions (login required)
 |
View Item |
