Kong, Zhi Xian and Karunakaran, Rina and Abdul Jabar, Kartini and Ponnampalavanar, Sasheela and Chong, Chun Wie and Teh, Cindy Shuan Ju (2021) The Detection of hypermucoviscous carbapenem-resistant klebsiella pneumoniae from a tertiary teaching hospital in Malaysia and assessment of hypermucoviscous as marker of hypervirulence. Microbial Drug Resistance, 27 (10). pp. 1319-1327. ISSN 1076-6294, DOI https://doi.org/10.1089/mdr.2020.0096.
Full text not available from this repository.Abstract
Background: Hypermucoviscous carbapenem-resistant Klebsiella pneumoniae (hmCRKp) is emerging globally and approaching the worst-case scenario in health care system. Aims: The main objective in this study was to determine the hypermucoviscous characteristics among the carbapenem-resistant K. pneumoniae (CRKp) isolated from a teaching hospital in Malaysia. The association of hypermucoviscous phenotype with the virulence traits and clinical presentations were also investigated. Methods: A retrospective study was conducted in University Malaya Medical Centre (UMMC). The presence of hypermucoviscous K. pneumoniae was identified among a collection of CRKp clinical isolates (first isolate per patient) from 2014 to 2015 using string test. Correlation between clinical and microbial characteristics of the hmCRKp was investigated. Results: A total of nine (7.5%) hmCRKp were detected among 120 CRKp isolates. Majority of the isolates were hospital acquired or health care-associated infections. None of the patients had typical pyogenic liver abscess. All of the hmCRKp isolates harbored carbapenemase genes and were multidrug resistant. K1/K serotype, peg-344, allS, and magA were not identified among hmCRKp isolates, whereas aerobactin siderophore receptor gene (iutA), iroB, rmpA, and rmpA2 were detected. Only three hmCRKp isolates were resistant to serum bactericidal. Conclusions: All the isolates presented inconclusive evidence for the interpretation of hypervirulence. Therefore, more study should be performed in the future to have a better understanding of the virulence mechanisms in correlation with the clinical and microbial determinants.
| Item Type: | Article |
|---|---|
| Funders: | International Society of Infectious Diseases (IF016-2015), Fundamental Research Grant Scheme (FP013-2018A) |
| Uncontrolled Keywords: | Carbapenem-resistant Klebsiella pneumoniae; Hypermucoviscous; Serum bactericidal; Virulence genes; Hypervirulence; Malaysia |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 29 Mar 2022 02:57 |
| Last Modified: | 29 Mar 2022 02:57 |
| URI: | http://eprints.um.edu.my/id/eprint/28512 |
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