Lim, Jasmine and Onozawa, Mizuki and Saad, Marniza and Ong, Teng Aik and Malek, Rohan and Akaza, Hideyuki and Study, A-CaP Asian Prostate Canc and Gr, J-CaP Japan Prostate Canc Study and Study, M-CaP Malaysia Prostate Canc (2021) Recent trend of androgen deprivation therapy in newly diagnosed prostate cancer patients: Comparing between high- and middle-income Asian countries. Cancer Science, 112 (6). pp. 2071-2080. ISSN 1347-9032, DOI https://doi.org/10.1111/cas.14889.
Full text not available from this repository.Abstract
The number of newly diagnosed prostate cancer cases varies across Asia, with higher mortality-to-incidence ratio reported in developing nations. Androgen deprivation therapy (ADT), alone or in combination, remains the mainstay of first-line treatment for advanced prostate cancer. Key findings of extensive research and randomized controlled trials have shaped current clinical practice and influenced clinical guideline recommendations. We describe here the recent trend of ADT in newly diagnosed prostate cancer for Asia focusing on Japan (high-income country) and Malaysia (middle-income country) based on the Asian Prostate Cancer (A-CaP) Study. The combination of radiotherapy and ADT or ADT alone was common in patients with intermediate-to-high risk localized and locally advanced disease. For metastatic prostate cancer, maximum androgen blockade (gonadotrophin-releasing hormone GnRH] agonist/antagonist plus antiandrogen) was prevalent among the Japanese patients while primary ADT alone with GnRH agonist/antagonist was widely practiced in the Malaysian cohort. Upfront combined therapy (ADT plus docetaxel or androgen receptor pathway inhibitor) has significantly improved the outcomes of patients with metastatic castration-naive prostate cancer. Its application, however, remains low in our cohorts due to patients' financial capacity and national health insurance coverage. Early detection remains the cornerstone in prostate cancer control to improve treatment outcome and patient survival.
| Item Type: | Article |
|---|---|
| Funders: | Kementerian Kesihatan Malaysia (NMRR-16-1340-31177), Takeda Pharmaceutical Company Ltd |
| Uncontrolled Keywords: | Abiraterone acetate; A-CaP Study; adjuvant ADT; Chemohormonal therapy; Metastatic prostate cancer |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 09 Aug 2022 07:12 |
| Last Modified: | 09 Aug 2022 07:12 |
| URI: | http://eprints.um.edu.my/id/eprint/28413 |
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