Wibrianto, Aswandi and Putri, Dinar F. and Sakti, Satya C. W. and Lee, Hwei Voon and Fahmi, Mochamad Z. (2021) Naproxen release aspect from boron-doped carbon nanodots as a bifunctional agent in cancer therapy. RSC Advances, 11 (59). pp. 37375-37382. ISSN 2046-2069, DOI https://doi.org/10.1039/d1ra06148h.
Full text not available from this repository.Abstract
In this present study, boron-carbon nanodots were synthesized by the hydrothermal method. Boron-carbon nanodots were prepared by varying the concentration ratios of boronic acid and citric acid: 1 : 25, 2 : 1, and 25 : 1, respectively. The precursors were then poured into a Teflon autoclave and heated at 240 degrees for 4 h. This research aims to synthesise and evaluate the potential of boron-carbon nanodots as a bioimaging agent and naproxen delivery carrier. An X-ray diffractogram showed that the boron-carbon nanodots were amorphous. To analyse the functional groups, FTIR and XPS analysis was carried out. Spectrofluorometric analysis (lambda(ex) 320 nm) showed that the formulation of boron-carbon nanodots 2 : 1 (BCD 2 : 1) has the most ideal fluorescent properties at lambda(em) 453 nm, whereas UV-vis analysis showed lambda(max) at 223 nm, with a quantum yield of 52.29%. A confocal laser scanning micrograph and toxicity test (MTT assays) showed that boron-carbon nanodots delivered naproxen efficiently with loading amount and loading efficiency of naproxen 28% and 65%, respectively. Furthermore, it induced an anticancer effect in HeLa cells. This result indicated that boron-carbon nanodots can be used as a bioimaging agent and naproxen delivery carrier.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Research and Technology Republic of Indonesia Research (463/UN3.15/PT/2021) |
| Uncontrolled Keywords: | Naproxen; Boron-doped carbon nanodots; Bifunctional agent; Cancer therapy |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 08 Jul 2022 03:34 |
| Last Modified: | 08 Jul 2022 03:34 |
| URI: | http://eprints.um.edu.my/id/eprint/28013 |
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