Sangaran, Pushpa Gandi and Ibrahim, Zaridatul Aini and Chik, Zamri and Mohamed, Zahurin and Ahmadiani, Abolhassan (2021) LPS preconditioning attenuates apoptosis mechanism by inhibiting NF-kappa B and caspase-3 activity: TLR4 pre-activation in the signaling pathway of LPS-induced Neuroprotection. Molecular Neurobiology, 58 (5). pp. 2407-2422. ISSN 0893-7648, DOI https://doi.org/10.1007/s12035-020-02227-3.
Full text not available from this repository.Abstract
Neuroinflammation, an inflammatory response within the nervous system, has been shown to be implicated in the progression of various neurodegenerative diseases. Recent in vivo studies showed that lipopolysaccharide (LPS) preconditioning provides neuroprotection by activating Toll-like receptor 4 (TLR4), one of the members for pattern recognition receptor (PRR) family that play critical role in host response to tissue injury, infection, and inflammation. Pre-exposure to low dose of LPS could confer a protective state against cellular apoptosis following subsequent stimulation with LPS at higher concentration, suggesting a role for TLR4 pre-activation in the signaling pathway of LPS-induced neuroprotection. However, the precise molecular mechanism associated with this protective effect is not well understood. In this article, we provide an overall review of the current state of our knowledge about LPS preconditioning in attenuating apoptosis mechanism and conferring neuroprotection via TLR4 signaling pathway.
| Item Type: | Article |
|---|---|
| Funders: | High Impact Research (HIR) (UM.C/625/1/HIR/172), High Impact Research (HIR) (PG123-2014B) |
| Uncontrolled Keywords: | Neuroinflammation; LPS preconditioning; Toll-like receptor 4 (TLR4); Apoptosis; Neuroprotection |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 06 Jul 2022 08:09 |
| Last Modified: | 06 Jul 2022 08:09 |
| URI: | http://eprints.um.edu.my/id/eprint/28002 |
Actions (login required)
 |
View Item |
