Koh, May-Yi and Lim, Kheng-Seang and Fong, Si Lei and Khor, Si Bao and Tan, Chong Tin (2021) Impact of COVID-19 on quality of life in people with epilepsy, and a multinational comparison of clinical and psychological impacts. Epilepsy & Behavior, 117. ISSN 1525-5050, DOI https://doi.org/10.1016/j.yebeh.2021.107849.
Full text not available from this repository.Abstract
Background: This study aimed to determine the relationship among the clinical, logistic, and psychological impacts of COVID-19 on people with epilepsy (PWE), and the impact of COVID-19 on the quality of life. Method: This is a cross-sectional anonymized web-based study on PWE, using an online questionnaire to assess the clinical, logistic, and psychological impacts of COVID-19, including Hospital Anxiety Depression Scale (HADS) and Quality of Life in Epilepsy Inventory (QOLIE-31). Result: 461 patients were recruited, with a mean age of 39.21 +/- 15.88 years, majority female (50.1%), with focal epilepsy (54.0%), and experienced seizures at least once yearly (62.5%). There were 13.0% experienced seizure worsening during COVID-19 period, which were associated with baseline seizures frequency >= 1 per month (32.0% vs. 6.2%, p < 0.001), worries of seizure worsening (18.0% vs. 10.9%, p < 0.001), difficulty to go emergency unit (24.4% vs. 10.4%, p < 0.001), AEDs ran out of stock (23.2% vs. 11.6%, p < 0.05), self-adjustment of AED dosages (26.4% vs. 11.3%, p < 0.001), inadequate sleep (22.4% vs. 9.2%, p < 0.001), and stress (23.4% vs.10.1%, p < 0.01). Participants experiencing seizure worsening reported greater anxiety (8.10 +/- 5.011 vs. 4.84 +/- 3.989, p < 0.001) and depression (6.05 +/- 3.868 vs. 3.86 +/- 3.589, p < 0.001). Logistic regression showed baseline seizures frequency >1 per month (OR, 14.10) followed by anxiety (OR, 3.90), inadequate sleep (OR, 0.37), and treated in UMMC (OR, 0.31) as the predictors for seizure worsening during COVID-19 period. Poorer total QOLIE-31 score was noted in those with seizure worsening (48.01 +/- 13.040 vs. 62.15 +/- 15.222, p < 0.001). Stepwise regression highlighted depression as the main negative predictor for quality of life (beta = -0.372, p < 0.001), followed by anxiety (b = -0.345, p < 0.001). Conclusion: A significant number of PWE experienced seizure worsening during COVID-19 period, which was related to the clinical, logistic, and psychological factors. Quality of life was affected by the seizure worsening and the psychological stress. (C) 2021 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Faculty of Medicine Postgraduate Scheme, Impact Oriented Interdisciplinary Research Grant (IIRG) Programme (IIRG003A2020HWB) |
| Uncontrolled Keywords: | COVID-19; Epilepsy; Seizure control; Quality of life; Depression; Anxiety |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 16 Jun 2022 07:52 |
| Last Modified: | 16 Jun 2022 07:52 |
| URI: | http://eprints.um.edu.my/id/eprint/27936 |
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