Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic?

Chandramathi, S.; Suresh, K.; Anita, Z.B.; Kuppusamy, U.R. (2012) Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic? Transactions of The Royal Society of Tropical Medicine and Hygiene. ISSN 0035-9203

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Abstract

Chemotherapy can cause immunosuppression, which may trigger latent intestinal parasitic infections in stools to emerge. This study investigated whether intestinal parasites can emerge as opportunistic infections in breast and colorectal cancer patients (n=46 and n=15, respectively) undergoing chemotherapy treatment. Breast cancer patients were receiving a 5-fluorouracil/epirubicin/cyclophosphamide (FEC) regimen (6 chemotherapy cycles), and colorectal cancer patients were receiving either an oxaliplatin/5-fluorouracil/folinic acid (FOLFOX) regimen (12 cycles) or a 5-fluorouracil/folinic acid (Mayo) regimen (6 cycles). Patients had Blastocystis hominis and microsporidia infections that were only present during the intermediate chemotherapy cycles. Thus, cancer patients undergoing chemotherapy should be screened repeatedly for intestinal parasites, namely B. hominis and microsporidia, as they may reduce the efficacy of chemotherapy treatments.

Item Type: Article
Creators:
  1. Chandramathi, S.
  2. Suresh, K.
  3. Anita, Z.B.
  4. Kuppusamy, U.R.
Journal or Publication Title: Transactions of The Royal Society of Tropical Medicine and Hygiene
Additional Information: Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Uncontrolled Keywords: Chemotherapy; Cancer
Subjects: R Medicine
Divisions: UNSPECIFIED
Depositing User: Mr. Faizal Hamzah
Date Deposited: 23 Feb 2012 11:04
Last Modified: 18 Nov 2013 09:39
URI: http://eprints.um.edu.my/id/eprint/2776

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