Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic?

Chandramathi, S. and Suresh, K. and Anita, Z.B. and Kuppusamy, Umah Rani (2012) Infections of Blastocystis hominis and microsporidia in cancer patients: are they opportunistic? Transactions of the Royal Society of Tropical Medicine and Hygiene, 106 (4). pp. 267-269. ISSN 0035-9203

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Official URL: https://doi.org/10.1016/j.trstmh.2011.12.008

Abstract

Chemotherapy can cause immunosuppression, which may trigger latent intestinal parasitic infections in stools to emerge. This study investigated whether intestinal parasites can emerge as opportunistic infections in breast and colorectal cancer patients (n=46 and n=15, respectively) undergoing chemotherapy treatment. Breast cancer patients were receiving a 5-fluorouracil/epirubicin/cyclophosphamide (FEC) regimen (6 chemotherapy cycles), and colorectal cancer patients were receiving either an oxaliplatin/5-fluorouracil/folinic acid (FOLFOX) regimen (12 cycles) or a 5-fluorouracil/folinic acid (Mayo) regimen (6 cycles). Patients had Blastocystis hominis and microsporidia infections that were only present during the intermediate chemotherapy cycles. Thus, cancer patients undergoing chemotherapy should be screened repeatedly for intestinal parasites, namely B. hominis and microsporidia, as they may reduce the efficacy of chemotherapy treatments.

Item Type: Article
Additional Information: Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Uncontrolled Keywords: Blastocystis hominis; Microsporidia; Opportunistic infection; Cancer; Chemotherapy
Subjects: R Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 23 Feb 2012 03:04
Last Modified: 18 Mar 2019 08:21
URI: http://eprints.um.edu.my/id/eprint/2776

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