Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast

Lee, Y.Y. and Bee, P.C. and Lee, C.K. and Naiker, M. and Ismail, R. (2011) Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast. Annals of Dermatology. ISSN 1013-9087, DOI 22346286.

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Official URL: http://www.ncbi.nlm.nih.gov/pubmed/22346286

Abstract

Bullous pemphigoid (BP) has a recognized association with solid organ tumors, but is relatively rare in hematological malignancies. We report a 67-year-old male who developed BP after being diagnosed with myelodysplastic syndrome and refractory anemia with excess of blast (RAEB). Skin biopsy elucidated sub-epidermal bulla using direct immunofluorescence, revealing linear C3 and IgG deposits along the basement membrane. His BP was recalcitrant to the conventional treatment and only responded to a combination of high dose oral prednisolone and azathioprine. The relative refractory nature of his condition and concurrent RAEB supports a paraneoplastic nature.

Item Type: Article
Funders: UNSPECIFIED
Additional Information: Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Uncontrolled Keywords: Bullous pemphigoid (BP)
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 23 Feb 2012 02:48
Last Modified: 30 Jan 2019 08:58
URI: http://eprints.um.edu.my/id/eprint/2773

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