Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast

Lee, Y.Y.; Bee, P.C.; Lee, C.K.; Naiker, M.; Ismail, R. (2011) Bullous pemphigoid in an elderly patient with myelodysplastic syndrome and refractory anemia coupled with excess of blast. Annals of Dermatology. ISSN 1013-9087

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Abstract

Bullous pemphigoid (BP) has a recognized association with solid organ tumors, but is relatively rare in hematological malignancies. We report a 67-year-old male who developed BP after being diagnosed with myelodysplastic syndrome and refractory anemia with excess of blast (RAEB). Skin biopsy elucidated sub-epidermal bulla using direct immunofluorescence, revealing linear C3 and IgG deposits along the basement membrane. His BP was recalcitrant to the conventional treatment and only responded to a combination of high dose oral prednisolone and azathioprine. The relative refractory nature of his condition and concurrent RAEB supports a paraneoplastic nature.

Item Type: Article
Creators:
  1. Lee, Y.Y.
  2. Bee, P.C.
  3. Lee, C.K.
  4. Naiker, M.
  5. Ismail, R.
Journal or Publication Title: Annals of Dermatology
Additional Information: Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Uncontrolled Keywords: Bullous pemphigoid (BP)
Subjects: R Medicine
Divisions: Faculty of Medicine
Depositing User: Mr. Faizal Hamzah
Date Deposited: 23 Feb 2012 10:48
Last Modified: 21 Dec 2014 16:04
URI: http://eprints.um.edu.my/id/eprint/2773

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