Perumalsamy, Sangeetha and Wan Ahmad, Wan Azman and Zaman Huri, Hasniza (2021) Single nucleotide polymorphism rs17173608 in the chemerin encoding gene: Is it a predictor of insulin resistance and severity of coronary artery disease in non-obese type 2 diabetes? Healthcare, 9 (6). ISSN 2227-9032, DOI https://doi.org/10.3390/healthcare9060623.
Full text not available from this repository.Abstract
(1) Background: Chemerin, or the RARRES2 (Retinoic Acid Receptor Responder 2) gene, is found to be associated with an increased incidence of insulin resistance, endothelial dysfunction, type 2 diabetes (T2D), and coronary artery disease (CAD). This study investigates associations of RARRES2 rs17173608 with insulin resistance and the severity of CAD in non-obese T2D patients in relation to the clinical and genetic factors. (2) Methods: A total of 300 patients with T2D and CAD were recruited in this study. The associations of insulin resistance and the severity of CAD with RARRES2 rs17173608 and clinical factors were assessed. The genotyping procedures were performed using the TaqMan method. The significant associations (p <= 0.05) from preliminary tests were employed to carry out the secondary analysis. (3) Results: RARRES2 rs17173608 (TT, TG, and GG polymorphisms in the preliminary analysis; TG and GG polymorphisms in a secondary analysis) was associated with insulin resistance and the severity of CAD in both the preliminary and secondary analysis (all p-values were < 0.05). Additionally, in the secondary analysis, FPG and ACEI were also associated with insulin resistance and the severity of CAD (all p-values were < 0.05). (4) Conclusion: From the preliminary findings, rs17173608 is a significant predictor of insulin resistance and the severity of CAD.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya (RP024B-14HTM), Universiti Malaya (PG173-2016A) |
| Uncontrolled Keywords: | Chemerin; RARRES2; rs17173608; Insulin resistance; T2D; severity of CAD |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine Faculty of Pharmacy |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 10 Jun 2022 01:55 |
| Last Modified: | 10 Jun 2022 01:55 |
| URI: | http://eprints.um.edu.my/id/eprint/27594 |
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