Sim, Edmund Ui-Hang and Lee, Choon Weng and Narayanan, Kumaran (2021) The roles of ribosomal proteins in nasopharyngeal cancer: Culprits, sentinels or both. Biomarker Research, 9 (1). ISSN 2050-7771, DOI https://doi.org/10.1186/s40364-021-00311-x.
Full text not available from this repository.Abstract
Ribosomal protein genes encode products that are essential for cellular protein biosynthesis and are major components of ribosomes. Canonically, they are involved in the complex system of ribosome biogenesis pivotal to the catalysis of protein translation. Amid this tightly organised process, some ribosomal proteins have unique spatial and temporal physiological activity giving rise to their extra-ribosomal functions. Many of these extra-ribosomal roles pertain to cellular growth and differentiation, thus implicating the involvement of some ribosomal proteins in organogenesis. Consequently, dysregulated functions of these ribosomal proteins could be linked to oncogenesis or neoplastic transformation of human cells. Their suspected roles in carcinogenesis have been reported but not specifically explained for malignancy of the nasopharynx. This is despite the fact that literature since one and half decade ago have documented the association of ribosomal proteins to nasopharyngeal cancer. In this review, we explain the association and contribution of dysregulated expression among a subset of ribosomal proteins to nasopharyngeal oncogenesis. The relationship of these ribosomal proteins with the cancer are explained. We provide information to indicate that the dysfunctional extra-ribosomal activities of specific ribosomal proteins are tightly involved with the molecular pathogenesis of nasopharyngeal cancer albeit mechanisms yet to be precisely defined. The complete knowledge of this will impact future applications in the effective management of nasopharyngeal cancer.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Energy, Science, Technology, Environment and Climate Change (MESTECC), Malaysia (IRPA-PR 06-02-09-1020-PR0054/05-020), Ministry of Health (JPP-IMR 06-064), Science and Technology Development Fund (STDF) Ministry of Higher Education & Scientific Research (MHESR) (RACE/a (1)/883/2012(01)), Science and Technology Development Fund (STDF) Ministry of Higher Education & Scientific Research (MHESR) (FRGS/ST03(01)/962/2013(03)), Science and Technology Development Fund (STDF) Ministry of Higher Education & Scientific Research (MHESR) (FRGS/ST03(02)/1299/2015(16)), Science and Technology Development Fund (STDF) Ministry of Higher Education & Scientific Research (MHESR) (F07/TRGS/1520/2016)), University of Malaya Research Collaboration Programme (UM.TNC2/IPPP/PPGP/261/PRPUM), Universiti Malaysia Sarawak PhD Fund (F07(DPP08)/1160/2014(08)) |
| Uncontrolled Keywords: | Ribosomal proteins; Nasopharyngeal carcinoma; Carcinogenesis; Cancer genetics; Medical genetics |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 31 May 2022 07:25 |
| Last Modified: | 31 May 2022 07:25 |
| URI: | http://eprints.um.edu.my/id/eprint/27205 |
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